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Towards a Consistent, Quantitative Evaluation of MicroRNA Evolution
The miRBase currently reports more than 25,000 microRNAs in several hundred genomes that belong to more than 1000 families of homologous sequences. Quantitative investigations of miRNA gene evolution requires the construction of data sets that are consistent in their coverage and include those genom...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
De Gruyter
2017
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6042801/ https://www.ncbi.nlm.nih.gov/pubmed/28637930 http://dx.doi.org/10.1515/jib-2016-0013 |
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author | Yazbeck, Ali M. Tout, Kifah R. Stadler, Peter F. Hertel, Jana |
author_facet | Yazbeck, Ali M. Tout, Kifah R. Stadler, Peter F. Hertel, Jana |
author_sort | Yazbeck, Ali M. |
collection | PubMed |
description | The miRBase currently reports more than 25,000 microRNAs in several hundred genomes that belong to more than 1000 families of homologous sequences. Quantitative investigations of miRNA gene evolution requires the construction of data sets that are consistent in their coverage and include those genomes that are of interest in a given study. Given the size and structure of data, this can be achieved only with the help of a fully automatic pipeline that improves the available seed alignments, extends the set of available sequences by homology search, and reliably identifies true positive homology search results. Here we describe the current progress towards such a system, emphasizing the task of improving and completing the initial seed alignment. |
format | Online Article Text |
id | pubmed-6042801 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2017 |
publisher | De Gruyter |
record_format | MEDLINE/PubMed |
spelling | pubmed-60428012019-01-28 Towards a Consistent, Quantitative Evaluation of MicroRNA Evolution Yazbeck, Ali M. Tout, Kifah R. Stadler, Peter F. Hertel, Jana J Integr Bioinform Article The miRBase currently reports more than 25,000 microRNAs in several hundred genomes that belong to more than 1000 families of homologous sequences. Quantitative investigations of miRNA gene evolution requires the construction of data sets that are consistent in their coverage and include those genomes that are of interest in a given study. Given the size and structure of data, this can be achieved only with the help of a fully automatic pipeline that improves the available seed alignments, extends the set of available sequences by homology search, and reliably identifies true positive homology search results. Here we describe the current progress towards such a system, emphasizing the task of improving and completing the initial seed alignment. De Gruyter 2017-06-05 /pmc/articles/PMC6042801/ /pubmed/28637930 http://dx.doi.org/10.1515/jib-2016-0013 Text en ©2017, Peter F. Stadler, published by De Gruyter, Berlin/Boston http://creativecommons.org/licenses/by-nc-nd/3.0 This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License. |
spellingShingle | Article Yazbeck, Ali M. Tout, Kifah R. Stadler, Peter F. Hertel, Jana Towards a Consistent, Quantitative Evaluation of MicroRNA Evolution |
title | Towards a Consistent, Quantitative Evaluation of MicroRNA Evolution |
title_full | Towards a Consistent, Quantitative Evaluation of MicroRNA Evolution |
title_fullStr | Towards a Consistent, Quantitative Evaluation of MicroRNA Evolution |
title_full_unstemmed | Towards a Consistent, Quantitative Evaluation of MicroRNA Evolution |
title_short | Towards a Consistent, Quantitative Evaluation of MicroRNA Evolution |
title_sort | towards a consistent, quantitative evaluation of microrna evolution |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6042801/ https://www.ncbi.nlm.nih.gov/pubmed/28637930 http://dx.doi.org/10.1515/jib-2016-0013 |
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