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Application of Computational Methods in Planaria Research: A Current Update
Planaria is a member of the Phylum Platyhelminthes including flatworms. Planarians possess the unique ability of regeneration from adult stem cells or neoblasts and finds importance as a model organism for regeneration and developmental studies. Although research is being actively carried out global...
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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De Gruyter
2017
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6042806/ https://www.ncbi.nlm.nih.gov/pubmed/28682786 http://dx.doi.org/10.1515/jib-2017-0007 |
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author | Ghosh, Shyamasree |
author_facet | Ghosh, Shyamasree |
author_sort | Ghosh, Shyamasree |
collection | PubMed |
description | Planaria is a member of the Phylum Platyhelminthes including flatworms. Planarians possess the unique ability of regeneration from adult stem cells or neoblasts and finds importance as a model organism for regeneration and developmental studies. Although research is being actively carried out globally through conventional methods to understand the process of regeneration from neoblasts, biology of development, neurobiology and immunology of Planaria, there are many thought provoking questions related to stem cell plasticity, and uniqueness of regenerative potential in Planarians amongst other members of Phylum Platyhelminthes. The complexity of receptors and signalling mechanisms, immune system network, biology of repair, responses to injury are yet to be understood in Planaria. Genomic and transcriptomic studies have generated a vast repository of data, but their availability and analysis is a challenging task. Data mining, computational approaches of gene curation, bioinformatics tools for analysis of transcriptomic data, designing of databases, application of algorithms in deciphering changes of morphology by RNA interference (RNAi) approaches, understanding regeneration experiments is a new venture in Planaria research that is helping researchers across the globe in understanding the biology. We highlight the applications of Hidden Markov models (HMMs) in designing of computational tools and their applications in Planaria decoding their complex biology. |
format | Online Article Text |
id | pubmed-6042806 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2017 |
publisher | De Gruyter |
record_format | MEDLINE/PubMed |
spelling | pubmed-60428062019-01-28 Application of Computational Methods in Planaria Research: A Current Update Ghosh, Shyamasree J Integr Bioinform Review Planaria is a member of the Phylum Platyhelminthes including flatworms. Planarians possess the unique ability of regeneration from adult stem cells or neoblasts and finds importance as a model organism for regeneration and developmental studies. Although research is being actively carried out globally through conventional methods to understand the process of regeneration from neoblasts, biology of development, neurobiology and immunology of Planaria, there are many thought provoking questions related to stem cell plasticity, and uniqueness of regenerative potential in Planarians amongst other members of Phylum Platyhelminthes. The complexity of receptors and signalling mechanisms, immune system network, biology of repair, responses to injury are yet to be understood in Planaria. Genomic and transcriptomic studies have generated a vast repository of data, but their availability and analysis is a challenging task. Data mining, computational approaches of gene curation, bioinformatics tools for analysis of transcriptomic data, designing of databases, application of algorithms in deciphering changes of morphology by RNA interference (RNAi) approaches, understanding regeneration experiments is a new venture in Planaria research that is helping researchers across the globe in understanding the biology. We highlight the applications of Hidden Markov models (HMMs) in designing of computational tools and their applications in Planaria decoding their complex biology. De Gruyter 2017-07-06 /pmc/articles/PMC6042806/ /pubmed/28682786 http://dx.doi.org/10.1515/jib-2017-0007 Text en ©2017, Shyamasree Ghosh, published by De Gruyter, Berlin/Boston http://creativecommons.org/licenses/by-nc-nd/3.0 This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License. |
spellingShingle | Review Ghosh, Shyamasree Application of Computational Methods in Planaria Research: A Current Update |
title | Application of Computational Methods in Planaria Research: A Current Update |
title_full | Application of Computational Methods in Planaria Research: A Current Update |
title_fullStr | Application of Computational Methods in Planaria Research: A Current Update |
title_full_unstemmed | Application of Computational Methods in Planaria Research: A Current Update |
title_short | Application of Computational Methods in Planaria Research: A Current Update |
title_sort | application of computational methods in planaria research: a current update |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6042806/ https://www.ncbi.nlm.nih.gov/pubmed/28682786 http://dx.doi.org/10.1515/jib-2017-0007 |
work_keys_str_mv | AT ghoshshyamasree applicationofcomputationalmethodsinplanariaresearchacurrentupdate |