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Analysis of cross-population differentiation between Thoroughbred and Jeju horses
OBJECTIVE: This study was intended to identify genes positively selected in Thoroughbred horses (THBs) that potentially contribute to their running performances. METHODS: The genomes of THB and Jeju horses (JH, Korean native horse) were compared to identify genes positively selected in THB. We perfo...
Autores principales: | , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Asian-Australasian Association of Animal Production Societies (AAAP) and Korean Society of Animal Science and Technology (KSAST)
2018
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6043458/ https://www.ncbi.nlm.nih.gov/pubmed/29268585 http://dx.doi.org/10.5713/ajas.17.0460 |
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author | Lee, Wonseok Park, Kyung-Do Taye, Mengistie Lee, Chul Kim, Heebal Lee, Hak-Kyo Shin, Donghyun |
author_facet | Lee, Wonseok Park, Kyung-Do Taye, Mengistie Lee, Chul Kim, Heebal Lee, Hak-Kyo Shin, Donghyun |
author_sort | Lee, Wonseok |
collection | PubMed |
description | OBJECTIVE: This study was intended to identify genes positively selected in Thoroughbred horses (THBs) that potentially contribute to their running performances. METHODS: The genomes of THB and Jeju horses (JH, Korean native horse) were compared to identify genes positively selected in THB. We performed cross-population extended haplotype homozygosity (XP-EHH) and cross-population composite likelihood ratio test (XP-CLR) statistical methods for our analysis using whole genome resequencing data of 14 THB and 6 JH. RESULTS: We identified 98 (XP-EHH) and 200 (XP-CLR) genes that are under positive selection in THB. Gene enrichment analysis identified 72 gene ontology biological process (GO BP) terms. The genes and GO BP terms explained some of THB’s characteristics such as immunity, energy metabolism and eye size and function related to running performances. GO BP terms that play key roles in several cell signaling mechanisms, which affected ocular size and visual functions were identified. GO BP term Eye photoreceptor cell differentiation is among the terms annotated presumed to affect eye size. CONCLUSION: Our analysis revealed some positively selected candidate genes in THB related to their racing performances. The genes detected are related to the immunity, ocular size and function, and energy metabolism. |
format | Online Article Text |
id | pubmed-6043458 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2018 |
publisher | Asian-Australasian Association of Animal Production Societies (AAAP) and Korean Society of Animal Science and Technology (KSAST) |
record_format | MEDLINE/PubMed |
spelling | pubmed-60434582018-08-01 Analysis of cross-population differentiation between Thoroughbred and Jeju horses Lee, Wonseok Park, Kyung-Do Taye, Mengistie Lee, Chul Kim, Heebal Lee, Hak-Kyo Shin, Donghyun Asian-Australas J Anim Sci Article OBJECTIVE: This study was intended to identify genes positively selected in Thoroughbred horses (THBs) that potentially contribute to their running performances. METHODS: The genomes of THB and Jeju horses (JH, Korean native horse) were compared to identify genes positively selected in THB. We performed cross-population extended haplotype homozygosity (XP-EHH) and cross-population composite likelihood ratio test (XP-CLR) statistical methods for our analysis using whole genome resequencing data of 14 THB and 6 JH. RESULTS: We identified 98 (XP-EHH) and 200 (XP-CLR) genes that are under positive selection in THB. Gene enrichment analysis identified 72 gene ontology biological process (GO BP) terms. The genes and GO BP terms explained some of THB’s characteristics such as immunity, energy metabolism and eye size and function related to running performances. GO BP terms that play key roles in several cell signaling mechanisms, which affected ocular size and visual functions were identified. GO BP term Eye photoreceptor cell differentiation is among the terms annotated presumed to affect eye size. CONCLUSION: Our analysis revealed some positively selected candidate genes in THB related to their racing performances. The genes detected are related to the immunity, ocular size and function, and energy metabolism. Asian-Australasian Association of Animal Production Societies (AAAP) and Korean Society of Animal Science and Technology (KSAST) 2018-08 2017-12-19 /pmc/articles/PMC6043458/ /pubmed/29268585 http://dx.doi.org/10.5713/ajas.17.0460 Text en Copyright © 2018 by Asian-Australasian Journal of Animal Sciences This is an open-access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0/), which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Article Lee, Wonseok Park, Kyung-Do Taye, Mengistie Lee, Chul Kim, Heebal Lee, Hak-Kyo Shin, Donghyun Analysis of cross-population differentiation between Thoroughbred and Jeju horses |
title | Analysis of cross-population differentiation between Thoroughbred and Jeju horses |
title_full | Analysis of cross-population differentiation between Thoroughbred and Jeju horses |
title_fullStr | Analysis of cross-population differentiation between Thoroughbred and Jeju horses |
title_full_unstemmed | Analysis of cross-population differentiation between Thoroughbred and Jeju horses |
title_short | Analysis of cross-population differentiation between Thoroughbred and Jeju horses |
title_sort | analysis of cross-population differentiation between thoroughbred and jeju horses |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6043458/ https://www.ncbi.nlm.nih.gov/pubmed/29268585 http://dx.doi.org/10.5713/ajas.17.0460 |
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