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Single neuron activity and c‐Fos expression in the rat striatum following electrical stimulation of the peripheral vestibular system
Connections between the vestibular system and the basal ganglia have been postulated since the early 20th century. However, the results of electrophysiological studies investigating neuronal responses to electrical stimulation of the vestibular system have been inconsistent. The aim of this study wa...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
John Wiley and Sons Inc.
2018
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6043475/ https://www.ncbi.nlm.nih.gov/pubmed/30003674 http://dx.doi.org/10.14814/phy2.13791 |
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author | Stiles, Lucy Reynolds, John N. Napper, Ruth Zheng, Yiwen Smith, Paul F. |
author_facet | Stiles, Lucy Reynolds, John N. Napper, Ruth Zheng, Yiwen Smith, Paul F. |
author_sort | Stiles, Lucy |
collection | PubMed |
description | Connections between the vestibular system and the basal ganglia have been postulated since the early 20th century. However, the results of electrophysiological studies investigating neuronal responses to electrical stimulation of the vestibular system have been inconsistent. The aim of this study was to investigate the effects of electrical stimulation of the vestibular labyrinth on single neuron activity and c‐Fos expression in the rat striatum. We used electrical stimulation of the vestibular labyrinth (various intensities delivered to the round window) to examine the electrophysiological response of striatal neurons and c‐Fos expression. From 507 single neurons recorded (n = 20 rats), no vestibular‐responsive neuron was found at 1× and 2× the nystagmus threshold; however, 6 neurons were found at 3× the threshold. These neurons were found bilaterally, with a response latency of ~50 msec from the end of the stimulus. For the c‐Fos study, the number of neurons expressing c‐Fos was quantified using stereological methods. Stimulation at 2× the threshold for nystagmus (n = 5 rats) resulted in a significant decrease in the number of neurons expressing c‐Fos in the bilateral striatum compared to both the sham control group (n = 5) and the lower stimulus intensity group (n = 5) (P ≤ 0.0001 for both). The results of this study demonstrate that: (1) some single striatal neurons respond to electrical vestibular stimulation, however, these responses are circumscribed and infrequent; (2) electrical stimulation of the vestibular labyrinth results in a decrease in the number of striatal neurons expressing c‐Fos, in a current‐dependent manner. |
format | Online Article Text |
id | pubmed-6043475 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2018 |
publisher | John Wiley and Sons Inc. |
record_format | MEDLINE/PubMed |
spelling | pubmed-60434752018-07-15 Single neuron activity and c‐Fos expression in the rat striatum following electrical stimulation of the peripheral vestibular system Stiles, Lucy Reynolds, John N. Napper, Ruth Zheng, Yiwen Smith, Paul F. Physiol Rep Original Research Connections between the vestibular system and the basal ganglia have been postulated since the early 20th century. However, the results of electrophysiological studies investigating neuronal responses to electrical stimulation of the vestibular system have been inconsistent. The aim of this study was to investigate the effects of electrical stimulation of the vestibular labyrinth on single neuron activity and c‐Fos expression in the rat striatum. We used electrical stimulation of the vestibular labyrinth (various intensities delivered to the round window) to examine the electrophysiological response of striatal neurons and c‐Fos expression. From 507 single neurons recorded (n = 20 rats), no vestibular‐responsive neuron was found at 1× and 2× the nystagmus threshold; however, 6 neurons were found at 3× the threshold. These neurons were found bilaterally, with a response latency of ~50 msec from the end of the stimulus. For the c‐Fos study, the number of neurons expressing c‐Fos was quantified using stereological methods. Stimulation at 2× the threshold for nystagmus (n = 5 rats) resulted in a significant decrease in the number of neurons expressing c‐Fos in the bilateral striatum compared to both the sham control group (n = 5) and the lower stimulus intensity group (n = 5) (P ≤ 0.0001 for both). The results of this study demonstrate that: (1) some single striatal neurons respond to electrical vestibular stimulation, however, these responses are circumscribed and infrequent; (2) electrical stimulation of the vestibular labyrinth results in a decrease in the number of striatal neurons expressing c‐Fos, in a current‐dependent manner. John Wiley and Sons Inc. 2018-07-12 /pmc/articles/PMC6043475/ /pubmed/30003674 http://dx.doi.org/10.14814/phy2.13791 Text en © 2018 The Authors. Physiological Reports published by Wiley Periodicals, Inc. on behalf of The Physiological Society and the American Physiological Society. This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Original Research Stiles, Lucy Reynolds, John N. Napper, Ruth Zheng, Yiwen Smith, Paul F. Single neuron activity and c‐Fos expression in the rat striatum following electrical stimulation of the peripheral vestibular system |
title | Single neuron activity and c‐Fos expression in the rat striatum following electrical stimulation of the peripheral vestibular system |
title_full | Single neuron activity and c‐Fos expression in the rat striatum following electrical stimulation of the peripheral vestibular system |
title_fullStr | Single neuron activity and c‐Fos expression in the rat striatum following electrical stimulation of the peripheral vestibular system |
title_full_unstemmed | Single neuron activity and c‐Fos expression in the rat striatum following electrical stimulation of the peripheral vestibular system |
title_short | Single neuron activity and c‐Fos expression in the rat striatum following electrical stimulation of the peripheral vestibular system |
title_sort | single neuron activity and c‐fos expression in the rat striatum following electrical stimulation of the peripheral vestibular system |
topic | Original Research |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6043475/ https://www.ncbi.nlm.nih.gov/pubmed/30003674 http://dx.doi.org/10.14814/phy2.13791 |
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