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Myelin Measurement: Comparison Between Simultaneous Tissue Relaxometry, Magnetization Transfer Saturation Index, and T(1)w/T(2)w Ratio Methods

Magnetization transfer (MT) imaging has been widely used for estimating myelin content in the brain. Recently, two other approaches, namely simultaneous tissue relaxometry of R(1) and R(2) relaxation rates and proton density (SyMRI) and the ratio of T(1)-weighted to T(2)-weighted images (T(1)w/T(2)w...

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Autores principales: Hagiwara, Akifumi, Hori, Masaaki, Kamagata, Koji, Warntjes, Marcel, Matsuyoshi, Daisuke, Nakazawa, Misaki, Ueda, Ryo, Andica, Christina, Koshino, Saori, Maekawa, Tomoko, Irie, Ryusuke, Takamura, Tomohiro, Kumamaru, Kanako Kunishima, Abe, Osamu, Aoki, Shigeki
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6043493/
https://www.ncbi.nlm.nih.gov/pubmed/30002497
http://dx.doi.org/10.1038/s41598-018-28852-6
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author Hagiwara, Akifumi
Hori, Masaaki
Kamagata, Koji
Warntjes, Marcel
Matsuyoshi, Daisuke
Nakazawa, Misaki
Ueda, Ryo
Andica, Christina
Koshino, Saori
Maekawa, Tomoko
Irie, Ryusuke
Takamura, Tomohiro
Kumamaru, Kanako Kunishima
Abe, Osamu
Aoki, Shigeki
author_facet Hagiwara, Akifumi
Hori, Masaaki
Kamagata, Koji
Warntjes, Marcel
Matsuyoshi, Daisuke
Nakazawa, Misaki
Ueda, Ryo
Andica, Christina
Koshino, Saori
Maekawa, Tomoko
Irie, Ryusuke
Takamura, Tomohiro
Kumamaru, Kanako Kunishima
Abe, Osamu
Aoki, Shigeki
author_sort Hagiwara, Akifumi
collection PubMed
description Magnetization transfer (MT) imaging has been widely used for estimating myelin content in the brain. Recently, two other approaches, namely simultaneous tissue relaxometry of R(1) and R(2) relaxation rates and proton density (SyMRI) and the ratio of T(1)-weighted to T(2)-weighted images (T(1)w/T(2)w ratio), were also proposed as methods for measuring myelin. SyMRI and MT imaging have been reported to correlate well with actual myelin by histology. However, for T(1)w/T(2)w ratio, such evidence is limited. In 20 healthy adults, we examined the correlation between these three methods, using MT saturation index (MT(sat)) for MT imaging. After calibration, white matter (WM) to gray matter (GM) contrast was the highest for SyMRI among these three metrics. Even though SyMRI and MT(sat) showed strong correlation in the WM (r = 0.72), only weak correlation was found between T(1)w/T(2)w and SyMRI (r = 0.45) or MT(sat) (r = 0.38) (correlation coefficients significantly different from each other, with p values < 0.001). In subcortical and cortical GM, these measurements showed moderate to strong correlations to each other (r = 0.54 to 0.78). In conclusion, the high correlation between SyMRI and MT(sat) indicates that both methods are similarly suited to measure myelin in the WM, whereas T(1)w/T(2)w ratio may be less optimal.
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spelling pubmed-60434932018-07-15 Myelin Measurement: Comparison Between Simultaneous Tissue Relaxometry, Magnetization Transfer Saturation Index, and T(1)w/T(2)w Ratio Methods Hagiwara, Akifumi Hori, Masaaki Kamagata, Koji Warntjes, Marcel Matsuyoshi, Daisuke Nakazawa, Misaki Ueda, Ryo Andica, Christina Koshino, Saori Maekawa, Tomoko Irie, Ryusuke Takamura, Tomohiro Kumamaru, Kanako Kunishima Abe, Osamu Aoki, Shigeki Sci Rep Article Magnetization transfer (MT) imaging has been widely used for estimating myelin content in the brain. Recently, two other approaches, namely simultaneous tissue relaxometry of R(1) and R(2) relaxation rates and proton density (SyMRI) and the ratio of T(1)-weighted to T(2)-weighted images (T(1)w/T(2)w ratio), were also proposed as methods for measuring myelin. SyMRI and MT imaging have been reported to correlate well with actual myelin by histology. However, for T(1)w/T(2)w ratio, such evidence is limited. In 20 healthy adults, we examined the correlation between these three methods, using MT saturation index (MT(sat)) for MT imaging. After calibration, white matter (WM) to gray matter (GM) contrast was the highest for SyMRI among these three metrics. Even though SyMRI and MT(sat) showed strong correlation in the WM (r = 0.72), only weak correlation was found between T(1)w/T(2)w and SyMRI (r = 0.45) or MT(sat) (r = 0.38) (correlation coefficients significantly different from each other, with p values < 0.001). In subcortical and cortical GM, these measurements showed moderate to strong correlations to each other (r = 0.54 to 0.78). In conclusion, the high correlation between SyMRI and MT(sat) indicates that both methods are similarly suited to measure myelin in the WM, whereas T(1)w/T(2)w ratio may be less optimal. Nature Publishing Group UK 2018-07-12 /pmc/articles/PMC6043493/ /pubmed/30002497 http://dx.doi.org/10.1038/s41598-018-28852-6 Text en © The Author(s) 2018 Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.
spellingShingle Article
Hagiwara, Akifumi
Hori, Masaaki
Kamagata, Koji
Warntjes, Marcel
Matsuyoshi, Daisuke
Nakazawa, Misaki
Ueda, Ryo
Andica, Christina
Koshino, Saori
Maekawa, Tomoko
Irie, Ryusuke
Takamura, Tomohiro
Kumamaru, Kanako Kunishima
Abe, Osamu
Aoki, Shigeki
Myelin Measurement: Comparison Between Simultaneous Tissue Relaxometry, Magnetization Transfer Saturation Index, and T(1)w/T(2)w Ratio Methods
title Myelin Measurement: Comparison Between Simultaneous Tissue Relaxometry, Magnetization Transfer Saturation Index, and T(1)w/T(2)w Ratio Methods
title_full Myelin Measurement: Comparison Between Simultaneous Tissue Relaxometry, Magnetization Transfer Saturation Index, and T(1)w/T(2)w Ratio Methods
title_fullStr Myelin Measurement: Comparison Between Simultaneous Tissue Relaxometry, Magnetization Transfer Saturation Index, and T(1)w/T(2)w Ratio Methods
title_full_unstemmed Myelin Measurement: Comparison Between Simultaneous Tissue Relaxometry, Magnetization Transfer Saturation Index, and T(1)w/T(2)w Ratio Methods
title_short Myelin Measurement: Comparison Between Simultaneous Tissue Relaxometry, Magnetization Transfer Saturation Index, and T(1)w/T(2)w Ratio Methods
title_sort myelin measurement: comparison between simultaneous tissue relaxometry, magnetization transfer saturation index, and t(1)w/t(2)w ratio methods
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6043493/
https://www.ncbi.nlm.nih.gov/pubmed/30002497
http://dx.doi.org/10.1038/s41598-018-28852-6
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