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Myelin Measurement: Comparison Between Simultaneous Tissue Relaxometry, Magnetization Transfer Saturation Index, and T(1)w/T(2)w Ratio Methods
Magnetization transfer (MT) imaging has been widely used for estimating myelin content in the brain. Recently, two other approaches, namely simultaneous tissue relaxometry of R(1) and R(2) relaxation rates and proton density (SyMRI) and the ratio of T(1)-weighted to T(2)-weighted images (T(1)w/T(2)w...
Autores principales: | , , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group UK
2018
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6043493/ https://www.ncbi.nlm.nih.gov/pubmed/30002497 http://dx.doi.org/10.1038/s41598-018-28852-6 |
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author | Hagiwara, Akifumi Hori, Masaaki Kamagata, Koji Warntjes, Marcel Matsuyoshi, Daisuke Nakazawa, Misaki Ueda, Ryo Andica, Christina Koshino, Saori Maekawa, Tomoko Irie, Ryusuke Takamura, Tomohiro Kumamaru, Kanako Kunishima Abe, Osamu Aoki, Shigeki |
author_facet | Hagiwara, Akifumi Hori, Masaaki Kamagata, Koji Warntjes, Marcel Matsuyoshi, Daisuke Nakazawa, Misaki Ueda, Ryo Andica, Christina Koshino, Saori Maekawa, Tomoko Irie, Ryusuke Takamura, Tomohiro Kumamaru, Kanako Kunishima Abe, Osamu Aoki, Shigeki |
author_sort | Hagiwara, Akifumi |
collection | PubMed |
description | Magnetization transfer (MT) imaging has been widely used for estimating myelin content in the brain. Recently, two other approaches, namely simultaneous tissue relaxometry of R(1) and R(2) relaxation rates and proton density (SyMRI) and the ratio of T(1)-weighted to T(2)-weighted images (T(1)w/T(2)w ratio), were also proposed as methods for measuring myelin. SyMRI and MT imaging have been reported to correlate well with actual myelin by histology. However, for T(1)w/T(2)w ratio, such evidence is limited. In 20 healthy adults, we examined the correlation between these three methods, using MT saturation index (MT(sat)) for MT imaging. After calibration, white matter (WM) to gray matter (GM) contrast was the highest for SyMRI among these three metrics. Even though SyMRI and MT(sat) showed strong correlation in the WM (r = 0.72), only weak correlation was found between T(1)w/T(2)w and SyMRI (r = 0.45) or MT(sat) (r = 0.38) (correlation coefficients significantly different from each other, with p values < 0.001). In subcortical and cortical GM, these measurements showed moderate to strong correlations to each other (r = 0.54 to 0.78). In conclusion, the high correlation between SyMRI and MT(sat) indicates that both methods are similarly suited to measure myelin in the WM, whereas T(1)w/T(2)w ratio may be less optimal. |
format | Online Article Text |
id | pubmed-6043493 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2018 |
publisher | Nature Publishing Group UK |
record_format | MEDLINE/PubMed |
spelling | pubmed-60434932018-07-15 Myelin Measurement: Comparison Between Simultaneous Tissue Relaxometry, Magnetization Transfer Saturation Index, and T(1)w/T(2)w Ratio Methods Hagiwara, Akifumi Hori, Masaaki Kamagata, Koji Warntjes, Marcel Matsuyoshi, Daisuke Nakazawa, Misaki Ueda, Ryo Andica, Christina Koshino, Saori Maekawa, Tomoko Irie, Ryusuke Takamura, Tomohiro Kumamaru, Kanako Kunishima Abe, Osamu Aoki, Shigeki Sci Rep Article Magnetization transfer (MT) imaging has been widely used for estimating myelin content in the brain. Recently, two other approaches, namely simultaneous tissue relaxometry of R(1) and R(2) relaxation rates and proton density (SyMRI) and the ratio of T(1)-weighted to T(2)-weighted images (T(1)w/T(2)w ratio), were also proposed as methods for measuring myelin. SyMRI and MT imaging have been reported to correlate well with actual myelin by histology. However, for T(1)w/T(2)w ratio, such evidence is limited. In 20 healthy adults, we examined the correlation between these three methods, using MT saturation index (MT(sat)) for MT imaging. After calibration, white matter (WM) to gray matter (GM) contrast was the highest for SyMRI among these three metrics. Even though SyMRI and MT(sat) showed strong correlation in the WM (r = 0.72), only weak correlation was found between T(1)w/T(2)w and SyMRI (r = 0.45) or MT(sat) (r = 0.38) (correlation coefficients significantly different from each other, with p values < 0.001). In subcortical and cortical GM, these measurements showed moderate to strong correlations to each other (r = 0.54 to 0.78). In conclusion, the high correlation between SyMRI and MT(sat) indicates that both methods are similarly suited to measure myelin in the WM, whereas T(1)w/T(2)w ratio may be less optimal. Nature Publishing Group UK 2018-07-12 /pmc/articles/PMC6043493/ /pubmed/30002497 http://dx.doi.org/10.1038/s41598-018-28852-6 Text en © The Author(s) 2018 Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/. |
spellingShingle | Article Hagiwara, Akifumi Hori, Masaaki Kamagata, Koji Warntjes, Marcel Matsuyoshi, Daisuke Nakazawa, Misaki Ueda, Ryo Andica, Christina Koshino, Saori Maekawa, Tomoko Irie, Ryusuke Takamura, Tomohiro Kumamaru, Kanako Kunishima Abe, Osamu Aoki, Shigeki Myelin Measurement: Comparison Between Simultaneous Tissue Relaxometry, Magnetization Transfer Saturation Index, and T(1)w/T(2)w Ratio Methods |
title | Myelin Measurement: Comparison Between Simultaneous Tissue Relaxometry, Magnetization Transfer Saturation Index, and T(1)w/T(2)w Ratio Methods |
title_full | Myelin Measurement: Comparison Between Simultaneous Tissue Relaxometry, Magnetization Transfer Saturation Index, and T(1)w/T(2)w Ratio Methods |
title_fullStr | Myelin Measurement: Comparison Between Simultaneous Tissue Relaxometry, Magnetization Transfer Saturation Index, and T(1)w/T(2)w Ratio Methods |
title_full_unstemmed | Myelin Measurement: Comparison Between Simultaneous Tissue Relaxometry, Magnetization Transfer Saturation Index, and T(1)w/T(2)w Ratio Methods |
title_short | Myelin Measurement: Comparison Between Simultaneous Tissue Relaxometry, Magnetization Transfer Saturation Index, and T(1)w/T(2)w Ratio Methods |
title_sort | myelin measurement: comparison between simultaneous tissue relaxometry, magnetization transfer saturation index, and t(1)w/t(2)w ratio methods |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6043493/ https://www.ncbi.nlm.nih.gov/pubmed/30002497 http://dx.doi.org/10.1038/s41598-018-28852-6 |
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