Avoiding hot-spots in Microwave-assisted Pd/C catalysed reactions by using the biomass derived solvent γ-Valerolactone

Herein, we report the use of γ-valerolactone as a new biomass-derived reaction medium for microwave assisted organic synthesis. The interaction of this solvent with microwaves and its heating profile under microwave irradiation has been fully characterized for the first time, demonstrating its stabi...

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Autores principales: Petricci, Elena, Risi, Caterina, Ferlin, Francesco, Lanari, Daniela, Vaccaro, Luigi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6043498/
https://www.ncbi.nlm.nih.gov/pubmed/30002506
http://dx.doi.org/10.1038/s41598-018-28458-y
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author Petricci, Elena
Risi, Caterina
Ferlin, Francesco
Lanari, Daniela
Vaccaro, Luigi
author_facet Petricci, Elena
Risi, Caterina
Ferlin, Francesco
Lanari, Daniela
Vaccaro, Luigi
author_sort Petricci, Elena
collection PubMed
description Herein, we report the use of γ-valerolactone as a new biomass-derived reaction medium for microwave assisted organic synthesis. The interaction of this solvent with microwaves and its heating profile under microwave irradiation has been fully characterized for the first time, demonstrating its stability and the applicability in microwave assisted Pd/C catalysed reactions avoiding the arcing phenomena frequently observed in these conditions. The use of γ-valerolactone demonstrated to be compatible with aliphatic and aromatic amines in the hydrogen transfer Pd/C mediated synthesis of benzimidazoles.
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spelling pubmed-60434982018-07-15 Avoiding hot-spots in Microwave-assisted Pd/C catalysed reactions by using the biomass derived solvent γ-Valerolactone Petricci, Elena Risi, Caterina Ferlin, Francesco Lanari, Daniela Vaccaro, Luigi Sci Rep Article Herein, we report the use of γ-valerolactone as a new biomass-derived reaction medium for microwave assisted organic synthesis. The interaction of this solvent with microwaves and its heating profile under microwave irradiation has been fully characterized for the first time, demonstrating its stability and the applicability in microwave assisted Pd/C catalysed reactions avoiding the arcing phenomena frequently observed in these conditions. The use of γ-valerolactone demonstrated to be compatible with aliphatic and aromatic amines in the hydrogen transfer Pd/C mediated synthesis of benzimidazoles. Nature Publishing Group UK 2018-07-12 /pmc/articles/PMC6043498/ /pubmed/30002506 http://dx.doi.org/10.1038/s41598-018-28458-y Text en © The Author(s) 2018 Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.
spellingShingle Article
Petricci, Elena
Risi, Caterina
Ferlin, Francesco
Lanari, Daniela
Vaccaro, Luigi
Avoiding hot-spots in Microwave-assisted Pd/C catalysed reactions by using the biomass derived solvent γ-Valerolactone
title Avoiding hot-spots in Microwave-assisted Pd/C catalysed reactions by using the biomass derived solvent γ-Valerolactone
title_full Avoiding hot-spots in Microwave-assisted Pd/C catalysed reactions by using the biomass derived solvent γ-Valerolactone
title_fullStr Avoiding hot-spots in Microwave-assisted Pd/C catalysed reactions by using the biomass derived solvent γ-Valerolactone
title_full_unstemmed Avoiding hot-spots in Microwave-assisted Pd/C catalysed reactions by using the biomass derived solvent γ-Valerolactone
title_short Avoiding hot-spots in Microwave-assisted Pd/C catalysed reactions by using the biomass derived solvent γ-Valerolactone
title_sort avoiding hot-spots in microwave-assisted pd/c catalysed reactions by using the biomass derived solvent γ-valerolactone
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6043498/
https://www.ncbi.nlm.nih.gov/pubmed/30002506
http://dx.doi.org/10.1038/s41598-018-28458-y
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