Lack of association between PER3 variable number tandem repeat and circadian rhythm sleep–wake disorders

Circadian rhythm sleep–wake disorders (CRSWDs) are characterized by disturbed sleep–wake patterns. We genotyped a PER3 variable number tandem repeat (VNTR) in 248 CRSWD individuals and 925 controls and found no significant association between the VNTR and CRSWDs or morningness–eveningness (diurnal)...

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Autores principales: Hida, Akiko, Kitamura, Shingo, Kadotani, Hiroshi, Uchiyama, Makoto, Ebisawa, Takashi, Inoue, Yuichi, Kamei, Yuichi, Mishima, Kazuo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Data Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6043536/
https://www.ncbi.nlm.nih.gov/pubmed/30083361
http://dx.doi.org/10.1038/s41439-018-0017-7
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author Hida, Akiko
Kitamura, Shingo
Kadotani, Hiroshi
Uchiyama, Makoto
Ebisawa, Takashi
Inoue, Yuichi
Kamei, Yuichi
Mishima, Kazuo
author_facet Hida, Akiko
Kitamura, Shingo
Kadotani, Hiroshi
Uchiyama, Makoto
Ebisawa, Takashi
Inoue, Yuichi
Kamei, Yuichi
Mishima, Kazuo
author_sort Hida, Akiko
collection PubMed
description Circadian rhythm sleep–wake disorders (CRSWDs) are characterized by disturbed sleep–wake patterns. We genotyped a PER3 variable number tandem repeat (VNTR) in 248 CRSWD individuals and 925 controls and found no significant association between the VNTR and CRSWDs or morningness–eveningness (diurnal) preferences in the Japanese population. Although the VNTR has been associated with circadian and sleep phenotypes in some other populations, the polymorphism may not be a universal genetic marker.
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spelling pubmed-60435362018-08-06 Lack of association between PER3 variable number tandem repeat and circadian rhythm sleep–wake disorders Hida, Akiko Kitamura, Shingo Kadotani, Hiroshi Uchiyama, Makoto Ebisawa, Takashi Inoue, Yuichi Kamei, Yuichi Mishima, Kazuo Hum Genome Var Data Report Circadian rhythm sleep–wake disorders (CRSWDs) are characterized by disturbed sleep–wake patterns. We genotyped a PER3 variable number tandem repeat (VNTR) in 248 CRSWD individuals and 925 controls and found no significant association between the VNTR and CRSWDs or morningness–eveningness (diurnal) preferences in the Japanese population. Although the VNTR has been associated with circadian and sleep phenotypes in some other populations, the polymorphism may not be a universal genetic marker. Nature Publishing Group UK 2018-07-12 /pmc/articles/PMC6043536/ /pubmed/30083361 http://dx.doi.org/10.1038/s41439-018-0017-7 Text en © The Author(s) 2018 Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.
spellingShingle Data Report
Hida, Akiko
Kitamura, Shingo
Kadotani, Hiroshi
Uchiyama, Makoto
Ebisawa, Takashi
Inoue, Yuichi
Kamei, Yuichi
Mishima, Kazuo
Lack of association between PER3 variable number tandem repeat and circadian rhythm sleep–wake disorders
title Lack of association between PER3 variable number tandem repeat and circadian rhythm sleep–wake disorders
title_full Lack of association between PER3 variable number tandem repeat and circadian rhythm sleep–wake disorders
title_fullStr Lack of association between PER3 variable number tandem repeat and circadian rhythm sleep–wake disorders
title_full_unstemmed Lack of association between PER3 variable number tandem repeat and circadian rhythm sleep–wake disorders
title_short Lack of association between PER3 variable number tandem repeat and circadian rhythm sleep–wake disorders
title_sort lack of association between per3 variable number tandem repeat and circadian rhythm sleep–wake disorders
topic Data Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6043536/
https://www.ncbi.nlm.nih.gov/pubmed/30083361
http://dx.doi.org/10.1038/s41439-018-0017-7
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