Cargando…

Genetic variation of SORBS1 gene is associated with glucose homeostasis and age at onset of diabetes: A SAPPHIRe Cohort Study

The SORBS1 gene plays an important role in insulin signaling. We aimed to examine whether common single-nucleotide polymorphisms (SNPs) of SORBS1 are associated with prevalence and incidence of diabetes, age at onset of diabetes, and the related traits of glucose homeostasis. A total of 1135 sibling...

Descripción completa

Detalles Bibliográficos
Autores principales: Chang, Tien-Jyun, Wang, Wen-Chang, Hsiung, Chao A., He, Chih-Tsueng, Lin, Ming-Wei, Sheu, Wayne Huey-Herng, Chang, Yi-Cheng, Quertermous, Tom, Chen, Yii-Der Ida, Rotter, Jerome I., Chuang, Lee-Ming
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6043583/
https://www.ncbi.nlm.nih.gov/pubmed/30002559
http://dx.doi.org/10.1038/s41598-018-28891-z
_version_ 1783339311801827328
author Chang, Tien-Jyun
Wang, Wen-Chang
Hsiung, Chao A.
He, Chih-Tsueng
Lin, Ming-Wei
Sheu, Wayne Huey-Herng
Chang, Yi-Cheng
Quertermous, Tom
Chen, Yii-Der Ida
Rotter, Jerome I.
Chuang, Lee-Ming
author_facet Chang, Tien-Jyun
Wang, Wen-Chang
Hsiung, Chao A.
He, Chih-Tsueng
Lin, Ming-Wei
Sheu, Wayne Huey-Herng
Chang, Yi-Cheng
Quertermous, Tom
Chen, Yii-Der Ida
Rotter, Jerome I.
Chuang, Lee-Ming
author_sort Chang, Tien-Jyun
collection PubMed
description The SORBS1 gene plays an important role in insulin signaling. We aimed to examine whether common single-nucleotide polymorphisms (SNPs) of SORBS1 are associated with prevalence and incidence of diabetes, age at onset of diabetes, and the related traits of glucose homeostasis. A total of 1135 siblings from 492 ethnic Chinese families were recruited at baseline, and 630 were followed up for 5.19 ± 0.96 years. Nine SNPs including rs7081076, rs2281939, rs3818540, rs2274490, rs61739184, rs726176, rs2296966, rs17849148, and rs3193970 were genotyped and examined. To deal with correlated data of subjects within the same families, the generalized estimating equations approach was applied throughout all association analyses. The GG genotype of rs2281939 was associated with a higher risk of diabetes at baseline, an earlier onset of diabetes, and higher steady-state plasma glucose levels in the modified insulin suppression test. The minor allele T of rs2296966 was associated with higher prevalence and incidence of diabetes, an earlier onset of diabetes, and higher 2-h glucose during oral glucose tolerance test. These two SNPs revealed independent associations with age of diabetes onset as well as risk of diabetes at baseline. These findings supported that SORBS1 gene participates in the pathogenesis of diabetes.
format Online
Article
Text
id pubmed-6043583
institution National Center for Biotechnology Information
language English
publishDate 2018
publisher Nature Publishing Group UK
record_format MEDLINE/PubMed
spelling pubmed-60435832018-07-15 Genetic variation of SORBS1 gene is associated with glucose homeostasis and age at onset of diabetes: A SAPPHIRe Cohort Study Chang, Tien-Jyun Wang, Wen-Chang Hsiung, Chao A. He, Chih-Tsueng Lin, Ming-Wei Sheu, Wayne Huey-Herng Chang, Yi-Cheng Quertermous, Tom Chen, Yii-Der Ida Rotter, Jerome I. Chuang, Lee-Ming Sci Rep Article The SORBS1 gene plays an important role in insulin signaling. We aimed to examine whether common single-nucleotide polymorphisms (SNPs) of SORBS1 are associated with prevalence and incidence of diabetes, age at onset of diabetes, and the related traits of glucose homeostasis. A total of 1135 siblings from 492 ethnic Chinese families were recruited at baseline, and 630 were followed up for 5.19 ± 0.96 years. Nine SNPs including rs7081076, rs2281939, rs3818540, rs2274490, rs61739184, rs726176, rs2296966, rs17849148, and rs3193970 were genotyped and examined. To deal with correlated data of subjects within the same families, the generalized estimating equations approach was applied throughout all association analyses. The GG genotype of rs2281939 was associated with a higher risk of diabetes at baseline, an earlier onset of diabetes, and higher steady-state plasma glucose levels in the modified insulin suppression test. The minor allele T of rs2296966 was associated with higher prevalence and incidence of diabetes, an earlier onset of diabetes, and higher 2-h glucose during oral glucose tolerance test. These two SNPs revealed independent associations with age of diabetes onset as well as risk of diabetes at baseline. These findings supported that SORBS1 gene participates in the pathogenesis of diabetes. Nature Publishing Group UK 2018-07-12 /pmc/articles/PMC6043583/ /pubmed/30002559 http://dx.doi.org/10.1038/s41598-018-28891-z Text en © The Author(s) 2018 Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.
spellingShingle Article
Chang, Tien-Jyun
Wang, Wen-Chang
Hsiung, Chao A.
He, Chih-Tsueng
Lin, Ming-Wei
Sheu, Wayne Huey-Herng
Chang, Yi-Cheng
Quertermous, Tom
Chen, Yii-Der Ida
Rotter, Jerome I.
Chuang, Lee-Ming
Genetic variation of SORBS1 gene is associated with glucose homeostasis and age at onset of diabetes: A SAPPHIRe Cohort Study
title Genetic variation of SORBS1 gene is associated with glucose homeostasis and age at onset of diabetes: A SAPPHIRe Cohort Study
title_full Genetic variation of SORBS1 gene is associated with glucose homeostasis and age at onset of diabetes: A SAPPHIRe Cohort Study
title_fullStr Genetic variation of SORBS1 gene is associated with glucose homeostasis and age at onset of diabetes: A SAPPHIRe Cohort Study
title_full_unstemmed Genetic variation of SORBS1 gene is associated with glucose homeostasis and age at onset of diabetes: A SAPPHIRe Cohort Study
title_short Genetic variation of SORBS1 gene is associated with glucose homeostasis and age at onset of diabetes: A SAPPHIRe Cohort Study
title_sort genetic variation of sorbs1 gene is associated with glucose homeostasis and age at onset of diabetes: a sapphire cohort study
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6043583/
https://www.ncbi.nlm.nih.gov/pubmed/30002559
http://dx.doi.org/10.1038/s41598-018-28891-z
work_keys_str_mv AT changtienjyun geneticvariationofsorbs1geneisassociatedwithglucosehomeostasisandageatonsetofdiabetesasapphirecohortstudy
AT wangwenchang geneticvariationofsorbs1geneisassociatedwithglucosehomeostasisandageatonsetofdiabetesasapphirecohortstudy
AT hsiungchaoa geneticvariationofsorbs1geneisassociatedwithglucosehomeostasisandageatonsetofdiabetesasapphirecohortstudy
AT hechihtsueng geneticvariationofsorbs1geneisassociatedwithglucosehomeostasisandageatonsetofdiabetesasapphirecohortstudy
AT linmingwei geneticvariationofsorbs1geneisassociatedwithglucosehomeostasisandageatonsetofdiabetesasapphirecohortstudy
AT sheuwaynehueyherng geneticvariationofsorbs1geneisassociatedwithglucosehomeostasisandageatonsetofdiabetesasapphirecohortstudy
AT changyicheng geneticvariationofsorbs1geneisassociatedwithglucosehomeostasisandageatonsetofdiabetesasapphirecohortstudy
AT quertermoustom geneticvariationofsorbs1geneisassociatedwithglucosehomeostasisandageatonsetofdiabetesasapphirecohortstudy
AT chenyiiderida geneticvariationofsorbs1geneisassociatedwithglucosehomeostasisandageatonsetofdiabetesasapphirecohortstudy
AT rotterjeromei geneticvariationofsorbs1geneisassociatedwithglucosehomeostasisandageatonsetofdiabetesasapphirecohortstudy
AT chuangleeming geneticvariationofsorbs1geneisassociatedwithglucosehomeostasisandageatonsetofdiabetesasapphirecohortstudy
AT geneticvariationofsorbs1geneisassociatedwithglucosehomeostasisandageatonsetofdiabetesasapphirecohortstudy