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Lineage marker synchrony in hematopoietic genealogies refutes the PU.1/GATA1 toggle switch paradigm
Molecular regulation of cell fate decisions underlies health and disease. To identify molecules that are active or regulated during a decision, and not before or after, the decision time point is crucial. However, cell fate markers are usually delayed and the time of decision therefore unknown. Fort...
Autores principales: | Strasser, Michael K., Hoppe, Philipp S., Loeffler, Dirk, Kokkaliaris, Konstantinos D., Schroeder, Timm, Theis, Fabian J., Marr, Carsten |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group UK
2018
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6043612/ https://www.ncbi.nlm.nih.gov/pubmed/30002371 http://dx.doi.org/10.1038/s41467-018-05037-3 |
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