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Metabolomics Reveals the Efficacy of Caspase Inhibition for Saikosaponin D-Induced Hepatotoxicity

Saikosaponin d (SSd) is a major hepatoprotective component of saikosaponins derived from Radix Bupleuri, which was also linked to hepatotoxicity. Previous studies have demonstrated that caspases play a key role in SSd-induced liver cell death. Our in vitro and in vivo studies also showed that treatm...

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Detalles Bibliográficos
Autores principales:	Zhang, Qian-qian, Huang, Wan-qiu, Gao, Yi-qiao, Han, Zhao-di, Zhang, Wei, Zhang, Zun-jian, Xu, Feng-guo
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2018
Materias:	Pharmacology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6043666/ https://www.ncbi.nlm.nih.gov/pubmed/30034340 http://dx.doi.org/10.3389/fphar.2018.00732

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