Cargando…

Effects of mesenchymal stem cells transplantation on cognitive deficits in animal models of Alzheimer’s disease: A systematic review and meta‐analysis

BACKGROUND: Alzheimer’s disease (AD) is a globally prevalent neurodegenerative disease, clinically characterized by progressive memory loss and gradual impairment of cognitive functions. Mesenchymal stem cells (MSCs) transplantation has been considered a possible therapeutic method for Alzheimer’s d...

Descripción completa

Detalles Bibliográficos
Autores principales: Ge, Meiling, Zhang, Yunxia, Hao, Qiukui, Zhao, Yunli, Dong, Birong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6043701/
https://www.ncbi.nlm.nih.gov/pubmed/29877067
http://dx.doi.org/10.1002/brb3.982
_version_ 1783339337208823808
author Ge, Meiling
Zhang, Yunxia
Hao, Qiukui
Zhao, Yunli
Dong, Birong
author_facet Ge, Meiling
Zhang, Yunxia
Hao, Qiukui
Zhao, Yunli
Dong, Birong
author_sort Ge, Meiling
collection PubMed
description BACKGROUND: Alzheimer’s disease (AD) is a globally prevalent neurodegenerative disease, clinically characterized by progressive memory loss and gradual impairment of cognitive functions. Mesenchymal stem cells (MSCs) transplantation has been considered a possible therapeutic method for Alzheimer’s disease (AD). However, no quantitative data synthesis of MSC therapy for AD exists. We conducted a systematic review and meta‐analysis to study the effects of MSCs on cognitive deficits in animal models of AD. METHODS: We identified eligible studies published from January 1980 to January 2017 by searching four electronic databases (PubMed, MEDLINE, EMBASE, CNKI). The endpoint was the effects of MSCs on cognitive performance evaluated by the Morris water maze (MWM) test including escape latency, and/or number of platform crossing, and/or time in the target quadrant. RESULTS: Nine preclinical studies incorporating 225 animals with AD were included for the meta‐analysis. The studies indicated that MSC‐based treatment significantly improved the learning function through measurements of the escape latency (SMD = −0.99, 95% CI = −1.33 to −0.64, p < .00001). Additionally, we observed that transplantation of MSCs significantly increased the number of platform crossing in six experiments (SMD = 0.78, 95% CI = 0.43 to 1.13, p < .0001). What’s more, the times in the target quadrant were increased in five studies indicated that transplantation of MSCs could ameliorate the cognitive impairments (SMD = 1.06, 95% CI = 0.46 to 1.67, p = .0005). CONCLUSIONS: This study showed that MSC transplantation could reduce cognitive deficits in AD models. These findings support the further studies to translate MSCs in the treatment of AD in humans
format Online
Article
Text
id pubmed-6043701
institution National Center for Biotechnology Information
language English
publishDate 2018
publisher John Wiley and Sons Inc.
record_format MEDLINE/PubMed
spelling pubmed-60437012018-07-15 Effects of mesenchymal stem cells transplantation on cognitive deficits in animal models of Alzheimer’s disease: A systematic review and meta‐analysis Ge, Meiling Zhang, Yunxia Hao, Qiukui Zhao, Yunli Dong, Birong Brain Behav Reviews BACKGROUND: Alzheimer’s disease (AD) is a globally prevalent neurodegenerative disease, clinically characterized by progressive memory loss and gradual impairment of cognitive functions. Mesenchymal stem cells (MSCs) transplantation has been considered a possible therapeutic method for Alzheimer’s disease (AD). However, no quantitative data synthesis of MSC therapy for AD exists. We conducted a systematic review and meta‐analysis to study the effects of MSCs on cognitive deficits in animal models of AD. METHODS: We identified eligible studies published from January 1980 to January 2017 by searching four electronic databases (PubMed, MEDLINE, EMBASE, CNKI). The endpoint was the effects of MSCs on cognitive performance evaluated by the Morris water maze (MWM) test including escape latency, and/or number of platform crossing, and/or time in the target quadrant. RESULTS: Nine preclinical studies incorporating 225 animals with AD were included for the meta‐analysis. The studies indicated that MSC‐based treatment significantly improved the learning function through measurements of the escape latency (SMD = −0.99, 95% CI = −1.33 to −0.64, p < .00001). Additionally, we observed that transplantation of MSCs significantly increased the number of platform crossing in six experiments (SMD = 0.78, 95% CI = 0.43 to 1.13, p < .0001). What’s more, the times in the target quadrant were increased in five studies indicated that transplantation of MSCs could ameliorate the cognitive impairments (SMD = 1.06, 95% CI = 0.46 to 1.67, p = .0005). CONCLUSIONS: This study showed that MSC transplantation could reduce cognitive deficits in AD models. These findings support the further studies to translate MSCs in the treatment of AD in humans John Wiley and Sons Inc. 2018-06-06 /pmc/articles/PMC6043701/ /pubmed/29877067 http://dx.doi.org/10.1002/brb3.982 Text en © 2018 The Authors. Brain and Behavior published by Wiley Periodicals, Inc. This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
spellingShingle Reviews
Ge, Meiling
Zhang, Yunxia
Hao, Qiukui
Zhao, Yunli
Dong, Birong
Effects of mesenchymal stem cells transplantation on cognitive deficits in animal models of Alzheimer’s disease: A systematic review and meta‐analysis
title Effects of mesenchymal stem cells transplantation on cognitive deficits in animal models of Alzheimer’s disease: A systematic review and meta‐analysis
title_full Effects of mesenchymal stem cells transplantation on cognitive deficits in animal models of Alzheimer’s disease: A systematic review and meta‐analysis
title_fullStr Effects of mesenchymal stem cells transplantation on cognitive deficits in animal models of Alzheimer’s disease: A systematic review and meta‐analysis
title_full_unstemmed Effects of mesenchymal stem cells transplantation on cognitive deficits in animal models of Alzheimer’s disease: A systematic review and meta‐analysis
title_short Effects of mesenchymal stem cells transplantation on cognitive deficits in animal models of Alzheimer’s disease: A systematic review and meta‐analysis
title_sort effects of mesenchymal stem cells transplantation on cognitive deficits in animal models of alzheimer’s disease: a systematic review and meta‐analysis
topic Reviews
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6043701/
https://www.ncbi.nlm.nih.gov/pubmed/29877067
http://dx.doi.org/10.1002/brb3.982
work_keys_str_mv AT gemeiling effectsofmesenchymalstemcellstransplantationoncognitivedeficitsinanimalmodelsofalzheimersdiseaseasystematicreviewandmetaanalysis
AT zhangyunxia effectsofmesenchymalstemcellstransplantationoncognitivedeficitsinanimalmodelsofalzheimersdiseaseasystematicreviewandmetaanalysis
AT haoqiukui effectsofmesenchymalstemcellstransplantationoncognitivedeficitsinanimalmodelsofalzheimersdiseaseasystematicreviewandmetaanalysis
AT zhaoyunli effectsofmesenchymalstemcellstransplantationoncognitivedeficitsinanimalmodelsofalzheimersdiseaseasystematicreviewandmetaanalysis
AT dongbirong effectsofmesenchymalstemcellstransplantationoncognitivedeficitsinanimalmodelsofalzheimersdiseaseasystematicreviewandmetaanalysis