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Impact of brain‐derived neurotrophic factor genetic polymorphism on cognition: A systematic review

INTRODUCTION: Brain‐derived neurotrophic factor (BDNF) has an important role in the neurogenesis and neuroplasticity of the brain. This systematic review was designed to examine the association between BDNF Val66Met (rs6265) polymorphism and four cognitive domains—attention and concentration, execut...

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Autores principales: Toh, Yi Long, Ng, Terence, Tan, Megan, Tan, Azrina, Chan, Alexandre
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6043712/
https://www.ncbi.nlm.nih.gov/pubmed/29858545
http://dx.doi.org/10.1002/brb3.1009
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author Toh, Yi Long
Ng, Terence
Tan, Megan
Tan, Azrina
Chan, Alexandre
author_facet Toh, Yi Long
Ng, Terence
Tan, Megan
Tan, Azrina
Chan, Alexandre
author_sort Toh, Yi Long
collection PubMed
description INTRODUCTION: Brain‐derived neurotrophic factor (BDNF) has an important role in the neurogenesis and neuroplasticity of the brain. This systematic review was designed to examine the association between BDNF Val66Met (rs6265) polymorphism and four cognitive domains—attention and concentration, executive function, verbal fluency, and memory, respectively. METHODOLOGY: Primary literature search was performed using search engines such as PubMed and Scopus. Observational studies that evaluated the neurocognitive performances in relation to BDNF polymorphism within human subjects were included in this review, while animal studies, overlapping studies, and meta‐analysis were excluded. RESULTS: Forty of 82 reviewed studies (48.8%) reported an association between Val66Met polymorphism and neurocognitive domains. The proportion of the studies showing positive findings in cognitive performances between Val/Val homozygotes and Met carriers was comparable, at 30.5% and 18.3%, respectively. The highest percentage of positive association between Val66Met polymorphism and neurocognition was reported under the memory domain, with 26 of 63 studies (41.3%), followed by 18 of 47 studies (38.3%) under the executive function domain and four of 23 studies (17.4%) under the attention and concentration domain. There were no studies showing an association between Val66Met polymorphism and verbal fluency. In particular, Val/Val homozygotes performed better in tasks related to the memory domain, while Met carriers performed better in terms of executive function, in both healthy individuals and clinical populations. CONCLUSION: While numerous studies report an association between Val66Met polymorphism and neurocognitive changes in executive function and memory domains, the effect of Met allele has not been clearly established.
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spelling pubmed-60437122018-07-15 Impact of brain‐derived neurotrophic factor genetic polymorphism on cognition: A systematic review Toh, Yi Long Ng, Terence Tan, Megan Tan, Azrina Chan, Alexandre Brain Behav Reviews INTRODUCTION: Brain‐derived neurotrophic factor (BDNF) has an important role in the neurogenesis and neuroplasticity of the brain. This systematic review was designed to examine the association between BDNF Val66Met (rs6265) polymorphism and four cognitive domains—attention and concentration, executive function, verbal fluency, and memory, respectively. METHODOLOGY: Primary literature search was performed using search engines such as PubMed and Scopus. Observational studies that evaluated the neurocognitive performances in relation to BDNF polymorphism within human subjects were included in this review, while animal studies, overlapping studies, and meta‐analysis were excluded. RESULTS: Forty of 82 reviewed studies (48.8%) reported an association between Val66Met polymorphism and neurocognitive domains. The proportion of the studies showing positive findings in cognitive performances between Val/Val homozygotes and Met carriers was comparable, at 30.5% and 18.3%, respectively. The highest percentage of positive association between Val66Met polymorphism and neurocognition was reported under the memory domain, with 26 of 63 studies (41.3%), followed by 18 of 47 studies (38.3%) under the executive function domain and four of 23 studies (17.4%) under the attention and concentration domain. There were no studies showing an association between Val66Met polymorphism and verbal fluency. In particular, Val/Val homozygotes performed better in tasks related to the memory domain, while Met carriers performed better in terms of executive function, in both healthy individuals and clinical populations. CONCLUSION: While numerous studies report an association between Val66Met polymorphism and neurocognitive changes in executive function and memory domains, the effect of Met allele has not been clearly established. John Wiley and Sons Inc. 2018-06-01 /pmc/articles/PMC6043712/ /pubmed/29858545 http://dx.doi.org/10.1002/brb3.1009 Text en © 2018 The Authors. Brain and Behavior published by Wiley Periodicals, Inc. This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
spellingShingle Reviews
Toh, Yi Long
Ng, Terence
Tan, Megan
Tan, Azrina
Chan, Alexandre
Impact of brain‐derived neurotrophic factor genetic polymorphism on cognition: A systematic review
title Impact of brain‐derived neurotrophic factor genetic polymorphism on cognition: A systematic review
title_full Impact of brain‐derived neurotrophic factor genetic polymorphism on cognition: A systematic review
title_fullStr Impact of brain‐derived neurotrophic factor genetic polymorphism on cognition: A systematic review
title_full_unstemmed Impact of brain‐derived neurotrophic factor genetic polymorphism on cognition: A systematic review
title_short Impact of brain‐derived neurotrophic factor genetic polymorphism on cognition: A systematic review
title_sort impact of brain‐derived neurotrophic factor genetic polymorphism on cognition: a systematic review
topic Reviews
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6043712/
https://www.ncbi.nlm.nih.gov/pubmed/29858545
http://dx.doi.org/10.1002/brb3.1009
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