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Comparison of different analysis algorithms to calculate multiple-breath washout outcomes

Lung clearance index (LCI) is the main outcome of the multiple-breath washout (MBW) test. Current recommendations for LCI acquisition are based on low-grade evidence. The aim of this study was to challenge those recommendations using alternative methods for LCI analysis. Nitrogen MBW measurements fr...

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Autores principales: Anagnostopoulou, Pinelopi, Kranz, Nadja, Wolfensberger, Jeremias, Guidi, Marisa, Nyilas, Sylvia, Koerner-Rettberg, Cordula, Yammine, Sophie, Singer, Florian, Latzin, Philipp
Formato: Online Artículo Texto
Lenguaje:English
Publicado: European Respiratory Society 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6043724/
https://www.ncbi.nlm.nih.gov/pubmed/30023402
http://dx.doi.org/10.1183/23120541.00021-2017
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author Anagnostopoulou, Pinelopi
Kranz, Nadja
Wolfensberger, Jeremias
Guidi, Marisa
Nyilas, Sylvia
Koerner-Rettberg, Cordula
Yammine, Sophie
Singer, Florian
Latzin, Philipp
author_facet Anagnostopoulou, Pinelopi
Kranz, Nadja
Wolfensberger, Jeremias
Guidi, Marisa
Nyilas, Sylvia
Koerner-Rettberg, Cordula
Yammine, Sophie
Singer, Florian
Latzin, Philipp
author_sort Anagnostopoulou, Pinelopi
collection PubMed
description Lung clearance index (LCI) is the main outcome of the multiple-breath washout (MBW) test. Current recommendations for LCI acquisition are based on low-grade evidence. The aim of this study was to challenge those recommendations using alternative methods for LCI analysis. Nitrogen MBW measurements from school-aged children, 20 healthy controls, 20 with cystic fibrosis (CF) and 17 with primary ciliary dyskinesia (PCD), were analysed using 1) current algorithms (standard), 2) three alternative algorithms to detect with higher precision the end of MBW testing and 3) two alternative algorithms to determine exhaled tracer gas concentrations. LCI values, intra-test repeatability, and ability to discriminate between health and lung disease were compared between these methods. The analysis methods strongly influenced LCI (mean±sd overall differences (%) between standard and alternative analysis methods: −4.9±5.7%; range: −66–19%), but did not improve intra-test variability. Discrimination between health and disease was comparable as areas under the receiver operator curves were not greater than that from standard analysis. This study supports current recommendations for LCI calculation in children. Alternative methods influence LCI estimates and hamper comparability between MBW setups. Alternative algorithms, whenever used, should be carefully reported.
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spelling pubmed-60437242018-07-18 Comparison of different analysis algorithms to calculate multiple-breath washout outcomes Anagnostopoulou, Pinelopi Kranz, Nadja Wolfensberger, Jeremias Guidi, Marisa Nyilas, Sylvia Koerner-Rettberg, Cordula Yammine, Sophie Singer, Florian Latzin, Philipp ERJ Open Res Original Articles Lung clearance index (LCI) is the main outcome of the multiple-breath washout (MBW) test. Current recommendations for LCI acquisition are based on low-grade evidence. The aim of this study was to challenge those recommendations using alternative methods for LCI analysis. Nitrogen MBW measurements from school-aged children, 20 healthy controls, 20 with cystic fibrosis (CF) and 17 with primary ciliary dyskinesia (PCD), were analysed using 1) current algorithms (standard), 2) three alternative algorithms to detect with higher precision the end of MBW testing and 3) two alternative algorithms to determine exhaled tracer gas concentrations. LCI values, intra-test repeatability, and ability to discriminate between health and lung disease were compared between these methods. The analysis methods strongly influenced LCI (mean±sd overall differences (%) between standard and alternative analysis methods: −4.9±5.7%; range: −66–19%), but did not improve intra-test variability. Discrimination between health and disease was comparable as areas under the receiver operator curves were not greater than that from standard analysis. This study supports current recommendations for LCI calculation in children. Alternative methods influence LCI estimates and hamper comparability between MBW setups. Alternative algorithms, whenever used, should be carefully reported. European Respiratory Society 2018-07-13 /pmc/articles/PMC6043724/ /pubmed/30023402 http://dx.doi.org/10.1183/23120541.00021-2017 Text en Copyright ©ERS 2018 http://creativecommons.org/licenses/by-nc/4.0/ This article is open access and distributed under the terms of the Creative Commons Attribution Non-Commercial Licence 4.0.
spellingShingle Original Articles
Anagnostopoulou, Pinelopi
Kranz, Nadja
Wolfensberger, Jeremias
Guidi, Marisa
Nyilas, Sylvia
Koerner-Rettberg, Cordula
Yammine, Sophie
Singer, Florian
Latzin, Philipp
Comparison of different analysis algorithms to calculate multiple-breath washout outcomes
title Comparison of different analysis algorithms to calculate multiple-breath washout outcomes
title_full Comparison of different analysis algorithms to calculate multiple-breath washout outcomes
title_fullStr Comparison of different analysis algorithms to calculate multiple-breath washout outcomes
title_full_unstemmed Comparison of different analysis algorithms to calculate multiple-breath washout outcomes
title_short Comparison of different analysis algorithms to calculate multiple-breath washout outcomes
title_sort comparison of different analysis algorithms to calculate multiple-breath washout outcomes
topic Original Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6043724/
https://www.ncbi.nlm.nih.gov/pubmed/30023402
http://dx.doi.org/10.1183/23120541.00021-2017
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