Cargando…
Radium and other alpha emitters in prostate cancer
(223)Radium ((223)Ra) is the first alpha-emitting therapy proven effective in human cancer. Prospective randomized trials indicate that (223)Ra, which concentrates after intravenous injection in areas of osteoblastic metastatic disease, can prolong survival in bone-dominant castrate resistant prosta...
Autores principales: | , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
AME Publishing Company
2018
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6043743/ https://www.ncbi.nlm.nih.gov/pubmed/30050802 http://dx.doi.org/10.21037/tau.2018.02.07 |
_version_ | 1783339346994135040 |
---|---|
author | Sartor, Oliver Sharma, Deepali |
author_facet | Sartor, Oliver Sharma, Deepali |
author_sort | Sartor, Oliver |
collection | PubMed |
description | (223)Radium ((223)Ra) is the first alpha-emitting therapy proven effective in human cancer. Prospective randomized trials indicate that (223)Ra, which concentrates after intravenous injection in areas of osteoblastic metastatic disease, can prolong survival in bone-dominant castrate resistant prostate cancer patients. Though radium isotopic therapy is conceptually critical to demonstrate that alpha emitters can be safe and effective, (223)Ra has inherent limitations given its restriction to bone metastatic disease. To overcome this limitation, targeted alpha therapy (TAT) is now being actively evaluated in prostate cancer, and other neoplasms. Key to TAT in prostate tumors in current studies is the overexpression of prostate specific membrane antigen (PSMA), a folate hydrolase expressed on the cell surface of malignant adenocarcinomas of the prostate. Using PSMA targeting (small molecules or antibodies), alpha emitting agents such as (225)Actinium ((225)Ac) or (213)Bismuth ((213)Bi) can be delivered to PSMA expressing tumors regardless of their metastatic location. Initial results from TAT in prostate cancer are highly promising and rapid development of these agents is anticipated in the years ahead assuming adequacy of isotope availability and appropriate clinical trial design. TAT may be develop as an independent approach, or synergize with a variety of other approaches including external beam radiation, hormonal therapies, chemotherapies, various radiation sensitizers, DNA repair inhibitors, and/or immune modulators. Clinical investigation opportunities in this field will rapidly increase in the years ahead. |
format | Online Article Text |
id | pubmed-6043743 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2018 |
publisher | AME Publishing Company |
record_format | MEDLINE/PubMed |
spelling | pubmed-60437432018-07-26 Radium and other alpha emitters in prostate cancer Sartor, Oliver Sharma, Deepali Transl Androl Urol Review Article (223)Radium ((223)Ra) is the first alpha-emitting therapy proven effective in human cancer. Prospective randomized trials indicate that (223)Ra, which concentrates after intravenous injection in areas of osteoblastic metastatic disease, can prolong survival in bone-dominant castrate resistant prostate cancer patients. Though radium isotopic therapy is conceptually critical to demonstrate that alpha emitters can be safe and effective, (223)Ra has inherent limitations given its restriction to bone metastatic disease. To overcome this limitation, targeted alpha therapy (TAT) is now being actively evaluated in prostate cancer, and other neoplasms. Key to TAT in prostate tumors in current studies is the overexpression of prostate specific membrane antigen (PSMA), a folate hydrolase expressed on the cell surface of malignant adenocarcinomas of the prostate. Using PSMA targeting (small molecules or antibodies), alpha emitting agents such as (225)Actinium ((225)Ac) or (213)Bismuth ((213)Bi) can be delivered to PSMA expressing tumors regardless of their metastatic location. Initial results from TAT in prostate cancer are highly promising and rapid development of these agents is anticipated in the years ahead assuming adequacy of isotope availability and appropriate clinical trial design. TAT may be develop as an independent approach, or synergize with a variety of other approaches including external beam radiation, hormonal therapies, chemotherapies, various radiation sensitizers, DNA repair inhibitors, and/or immune modulators. Clinical investigation opportunities in this field will rapidly increase in the years ahead. AME Publishing Company 2018-06 /pmc/articles/PMC6043743/ /pubmed/30050802 http://dx.doi.org/10.21037/tau.2018.02.07 Text en 2018 Translational Andrology and Urology. All rights reserved. |
spellingShingle | Review Article Sartor, Oliver Sharma, Deepali Radium and other alpha emitters in prostate cancer |
title | Radium and other alpha emitters in prostate cancer |
title_full | Radium and other alpha emitters in prostate cancer |
title_fullStr | Radium and other alpha emitters in prostate cancer |
title_full_unstemmed | Radium and other alpha emitters in prostate cancer |
title_short | Radium and other alpha emitters in prostate cancer |
title_sort | radium and other alpha emitters in prostate cancer |
topic | Review Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6043743/ https://www.ncbi.nlm.nih.gov/pubmed/30050802 http://dx.doi.org/10.21037/tau.2018.02.07 |
work_keys_str_mv | AT sartoroliver radiumandotheralphaemittersinprostatecancer AT sharmadeepali radiumandotheralphaemittersinprostatecancer |