Serum neurofilament light chain is increased in hereditary spastic paraplegias

Blood biomarkers are still largely missing in hereditary spastic paraplegias (HSPs). We here explored Neurofilament light chain (NfL) as a biomarker in HSP. Serum NfL was assessed in 96 HSP (63 genetically confirmed), 96 healthy control, and 33 ALS subjects by single molecule array (Simoa). Compared...

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Autores principales: Wilke, Carlo, Rattay, Tim W., Hengel, Holger, Zimmermann, Milan, Brockmann, Kathrin, Schöls, Ludger, Kuhle, Jens, Schüle, Rebecca, Synofzik, Matthis
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2018
Materias:
Brief Communications
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6043776/
https://www.ncbi.nlm.nih.gov/pubmed/30009206
http://dx.doi.org/10.1002/acn3.583
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author Wilke, Carlo
Rattay, Tim W.
Hengel, Holger
Zimmermann, Milan
Brockmann, Kathrin
Schöls, Ludger
Kuhle, Jens
Schüle, Rebecca
Synofzik, Matthis
author_facet Wilke, Carlo
Rattay, Tim W.
Hengel, Holger
Zimmermann, Milan
Brockmann, Kathrin
Schöls, Ludger
Kuhle, Jens
Schüle, Rebecca
Synofzik, Matthis
author_sort Wilke, Carlo
collection PubMed
description Blood biomarkers are still largely missing in hereditary spastic paraplegias (HSPs). We here explored Neurofilament light chain (NfL) as a biomarker in HSP. Serum NfL was assessed in 96 HSP (63 genetically confirmed), 96 healthy control, and 33 ALS subjects by single molecule array (Simoa). Compared to controls, NfL was increased in HSP (P < 0.001), correlating with cross‐sectional disease progression (ρ = 0.28). Levels were lower than in ALS (P < 0.001), allowing to differentiate HSP from ALS (AUC = 0.91). Serum NfL might serve as a biomarker in HSP indicating neuronal damage and, if confirmed longitudinally, disease progression. It might also support differentiating HSP from ALS.
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spelling pubmed-60437762018-07-15 Serum neurofilament light chain is increased in hereditary spastic paraplegias Wilke, Carlo Rattay, Tim W. Hengel, Holger Zimmermann, Milan Brockmann, Kathrin Schöls, Ludger Kuhle, Jens Schüle, Rebecca Synofzik, Matthis Ann Clin Transl Neurol Brief Communications Blood biomarkers are still largely missing in hereditary spastic paraplegias (HSPs). We here explored Neurofilament light chain (NfL) as a biomarker in HSP. Serum NfL was assessed in 96 HSP (63 genetically confirmed), 96 healthy control, and 33 ALS subjects by single molecule array (Simoa). Compared to controls, NfL was increased in HSP (P < 0.001), correlating with cross‐sectional disease progression (ρ = 0.28). Levels were lower than in ALS (P < 0.001), allowing to differentiate HSP from ALS (AUC = 0.91). Serum NfL might serve as a biomarker in HSP indicating neuronal damage and, if confirmed longitudinally, disease progression. It might also support differentiating HSP from ALS. John Wiley and Sons Inc. 2018-05-21 /pmc/articles/PMC6043776/ /pubmed/30009206 http://dx.doi.org/10.1002/acn3.583 Text en © 2018 The Authors. Annals of Clinical and Translational Neurology published by Wiley Periodicals, Inc on behalf of American Neurological Association. This is an open access article under the terms of the http://creativecommons.org/licenses/by-nc-nd/4.0/ License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non‐commercial and no modifications or adaptations are made.
spellingShingle Brief Communications
Wilke, Carlo
Rattay, Tim W.
Hengel, Holger
Zimmermann, Milan
Brockmann, Kathrin
Schöls, Ludger
Kuhle, Jens
Schüle, Rebecca
Synofzik, Matthis
Serum neurofilament light chain is increased in hereditary spastic paraplegias
title Serum neurofilament light chain is increased in hereditary spastic paraplegias
title_full Serum neurofilament light chain is increased in hereditary spastic paraplegias
title_fullStr Serum neurofilament light chain is increased in hereditary spastic paraplegias
title_full_unstemmed Serum neurofilament light chain is increased in hereditary spastic paraplegias
title_short Serum neurofilament light chain is increased in hereditary spastic paraplegias
title_sort serum neurofilament light chain is increased in hereditary spastic paraplegias
topic Brief Communications
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6043776/
https://www.ncbi.nlm.nih.gov/pubmed/30009206
http://dx.doi.org/10.1002/acn3.583
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