Gastric neuroendocrine carcinoma with positive staining for prostate cancer markers including prostate-specific antigen and alpha-methylacyl-CoA racemase

We report a case with prostate cancer and gastric neuroendocrine carcinoma. A 72-year old male presented with a gastric lesion 5 months after radical prostatectomy. The lesion was immunohistochemically positive for PSA, alpha-methylacyl-CoA racemase, synaptophysin, and chromogranin A, but negative f...

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Detalles Bibliográficos
Autores principales: Hakozaki, Yuji, Murata, Taro, Yokoyama, Munehiro, Matsushima, Hisashi, Ogawa, Maki, Masuda, Tomoko, Hirai, Yoko, Kume, Haruki
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2018
Materias:
Oncology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6043815/
https://www.ncbi.nlm.nih.gov/pubmed/30009133
http://dx.doi.org/10.1016/j.eucr.2018.07.008
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author Hakozaki, Yuji
Murata, Taro
Yokoyama, Munehiro
Matsushima, Hisashi
Ogawa, Maki
Masuda, Tomoko
Hirai, Yoko
Kume, Haruki
author_facet Hakozaki, Yuji
Murata, Taro
Yokoyama, Munehiro
Matsushima, Hisashi
Ogawa, Maki
Masuda, Tomoko
Hirai, Yoko
Kume, Haruki
author_sort Hakozaki, Yuji
collection PubMed
description We report a case with prostate cancer and gastric neuroendocrine carcinoma. A 72-year old male presented with a gastric lesion 5 months after radical prostatectomy. The lesion was immunohistochemically positive for PSA, alpha-methylacyl-CoA racemase, synaptophysin, and chromogranin A, but negative for androgen receptor (AR). Differentiating gastric neuroendocrine carcinoma from gastric metastasis of prostate cancer is difficult, as both lesions exhibit similar acinar cell proliferation with prominent nucleoli.(1) We discuss the diagnostic process of this case and how AR was a useful specific marker for diagnosing primary gastric neuroendocrine carcinoma.
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spelling pubmed-60438152018-07-13 Gastric neuroendocrine carcinoma with positive staining for prostate cancer markers including prostate-specific antigen and alpha-methylacyl-CoA racemase Hakozaki, Yuji Murata, Taro Yokoyama, Munehiro Matsushima, Hisashi Ogawa, Maki Masuda, Tomoko Hirai, Yoko Kume, Haruki Urol Case Rep Oncology We report a case with prostate cancer and gastric neuroendocrine carcinoma. A 72-year old male presented with a gastric lesion 5 months after radical prostatectomy. The lesion was immunohistochemically positive for PSA, alpha-methylacyl-CoA racemase, synaptophysin, and chromogranin A, but negative for androgen receptor (AR). Differentiating gastric neuroendocrine carcinoma from gastric metastasis of prostate cancer is difficult, as both lesions exhibit similar acinar cell proliferation with prominent nucleoli.(1) We discuss the diagnostic process of this case and how AR was a useful specific marker for diagnosing primary gastric neuroendocrine carcinoma. Elsevier 2018-07-07 /pmc/articles/PMC6043815/ /pubmed/30009133 http://dx.doi.org/10.1016/j.eucr.2018.07.008 Text en © 2018 The Authors http://creativecommons.org/licenses/by-nc-nd/4.0/ This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Oncology
Hakozaki, Yuji
Murata, Taro
Yokoyama, Munehiro
Matsushima, Hisashi
Ogawa, Maki
Masuda, Tomoko
Hirai, Yoko
Kume, Haruki
Gastric neuroendocrine carcinoma with positive staining for prostate cancer markers including prostate-specific antigen and alpha-methylacyl-CoA racemase
title Gastric neuroendocrine carcinoma with positive staining for prostate cancer markers including prostate-specific antigen and alpha-methylacyl-CoA racemase
title_full Gastric neuroendocrine carcinoma with positive staining for prostate cancer markers including prostate-specific antigen and alpha-methylacyl-CoA racemase
title_fullStr Gastric neuroendocrine carcinoma with positive staining for prostate cancer markers including prostate-specific antigen and alpha-methylacyl-CoA racemase
title_full_unstemmed Gastric neuroendocrine carcinoma with positive staining for prostate cancer markers including prostate-specific antigen and alpha-methylacyl-CoA racemase
title_short Gastric neuroendocrine carcinoma with positive staining for prostate cancer markers including prostate-specific antigen and alpha-methylacyl-CoA racemase
title_sort gastric neuroendocrine carcinoma with positive staining for prostate cancer markers including prostate-specific antigen and alpha-methylacyl-coa racemase
topic Oncology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6043815/
https://www.ncbi.nlm.nih.gov/pubmed/30009133
http://dx.doi.org/10.1016/j.eucr.2018.07.008
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