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Mechanism of membrane pore formation by human gasdermin‐D

Gasdermin‐D (GSDMD), a member of the gasdermin protein family, mediates pyroptosis in human and murine cells. Cleaved by inflammatory caspases, GSDMD inserts its N‐terminal domain (GSDMD(Nterm)) into cellular membranes and assembles large oligomeric complexes permeabilizing the membrane. So far, the...

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Detalles Bibliográficos
Autores principales:	Mulvihill, Estefania, Sborgi, Lorenzo, Mari, Stefania A, Pfreundschuh, Moritz, Hiller, Sebastian, Müller, Daniel J
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	John Wiley and Sons Inc. 2018
Materias:	Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6043855/ https://www.ncbi.nlm.nih.gov/pubmed/29898893 http://dx.doi.org/10.15252/embj.201798321

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