Retrospective analysis of primary plasma cell leukemia in Kansai Myeloma Forum registry

We retrospectively analyzed twenty-six patients with primary plasma cell leukemia (pPCL) registered from May 2005 until April 2015 by the Kansai Myeloma Forum. Twenty patients received novel agents (bortezomib or lenalidomide), and their median survival of was 34 months. The median survival of patie...

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Detalles Bibliográficos
Autores principales: Nakaya, Aya, Yagi, Hideo, Kaneko, Hitomi, Kosugi, Satoru, Kida, Toru, Adachi, Yoko, Shibayama, Hirohiko, Kohara, Takae, Kamitsuji, Yuri, Fuchida, Shin-ichi, Uoshima, Nobuhiko, Kawata, Eri, Uchiyama, Hitoji, Shimura, Yuji, Takahashi, Takayuki, Urase, Fumiaki, Ohta, Kensuke, Hamada, Tsuneyoshi, Miyamoto, Kazue, Kobayashi, Masayuki, Shindo, Maki, Tanaka, Hirokazu, Shimazaki, Chihiro, Hino, Masayuki, Kuroda, Junya, Kanakura, Yuzuru, Takaoari-Kondo, Akifumi, Nomura, Shosaku, Matsumura, Itaru
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6043871/
https://www.ncbi.nlm.nih.gov/pubmed/30013912
http://dx.doi.org/10.1016/j.lrr.2018.07.001
Descripción
Sumario:We retrospectively analyzed twenty-six patients with primary plasma cell leukemia (pPCL) registered from May 2005 until April 2015 by the Kansai Myeloma Forum. Twenty patients received novel agents (bortezomib or lenalidomide), and their median survival of was 34 months. The median survival of patients who underwent autologous stem cell transplantation (SCT) was 40 months, those undergoing allogeneic SCT 55 months, and those undergoing both types of SCT (auto–allo) 61 months; whereas for those who did not undergo SCT it was 28 months (p = 0.845). The only statistically significant risk factor identified by multivariate analysis was hypercalcemia.

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