Binding mechanism of anti-cancer chemotherapeutic drug mitoxantrone to DNA characterized by magnetic tweezers

BACKGROUND: Chemotherapeutic agents (anti-cancer drugs) are small cytostatic or cytotoxic molecules that often bind to double-stranded DNA (dsDNA) resulting in modifications of their structural and nanomechanical properties and thus interfering with the cell proliferation process. METHODS: We invest...

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Detalles Bibliográficos
Autores principales: Kreft, Dennis, Wang, Ying, Rattay, Michael, Toensing, Katja, Anselmetti, Dario
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2018
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6043947/
https://www.ncbi.nlm.nih.gov/pubmed/30005668
http://dx.doi.org/10.1186/s12951-018-0381-y

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