Nanostructured lipid carriers for MicroRNA delivery in tumor gene therapy

MicroRNAs (miRNAs), which are endogenous about 20–23 nucleotides non-coding RNAs, have been acted as post-transcriptional regulators of gene expression. Current studies demonstrated that miRNAs are promising candidates for tumor gene therapy because of their important biological functions in tumor c...

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Autores principales: Wang, Hairong, Liu, Shiming, Jia, Li, Chu, Fengyun, Zhou, Ya, He, Zhixu, Guo, Mengmeng, Chen, Chao, Xu, Lin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2018
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6043968/
https://www.ncbi.nlm.nih.gov/pubmed/30008618
http://dx.doi.org/10.1186/s12935-018-0596-x
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author Wang, Hairong
Liu, Shiming
Jia, Li
Chu, Fengyun
Zhou, Ya
He, Zhixu
Guo, Mengmeng
Chen, Chao
Xu, Lin
author_facet Wang, Hairong
Liu, Shiming
Jia, Li
Chu, Fengyun
Zhou, Ya
He, Zhixu
Guo, Mengmeng
Chen, Chao
Xu, Lin
author_sort Wang, Hairong
collection PubMed
description MicroRNAs (miRNAs), which are endogenous about 20–23 nucleotides non-coding RNAs, have been acted as post-transcriptional regulators of gene expression. Current studies demonstrated that miRNAs are promising candidates for tumor gene therapy because of their important biological functions in tumor cell proliferation, metastasis, apoptosis, and drug resistance. As an important delivery system, nanostructured lipid carriers (NLCs) have great potential in tumor gene therapy, particularly for miRNA delivery, due to low toxicity, low immunogenicity, long metabolic cycles, and easy modification. This article reviews recent research progress on NLCs for miRNA delivery in tumor gene therapy and prospective applications.
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spelling pubmed-60439682018-07-13 Nanostructured lipid carriers for MicroRNA delivery in tumor gene therapy Wang, Hairong Liu, Shiming Jia, Li Chu, Fengyun Zhou, Ya He, Zhixu Guo, Mengmeng Chen, Chao Xu, Lin Cancer Cell Int Review MicroRNAs (miRNAs), which are endogenous about 20–23 nucleotides non-coding RNAs, have been acted as post-transcriptional regulators of gene expression. Current studies demonstrated that miRNAs are promising candidates for tumor gene therapy because of their important biological functions in tumor cell proliferation, metastasis, apoptosis, and drug resistance. As an important delivery system, nanostructured lipid carriers (NLCs) have great potential in tumor gene therapy, particularly for miRNA delivery, due to low toxicity, low immunogenicity, long metabolic cycles, and easy modification. This article reviews recent research progress on NLCs for miRNA delivery in tumor gene therapy and prospective applications. BioMed Central 2018-07-13 /pmc/articles/PMC6043968/ /pubmed/30008618 http://dx.doi.org/10.1186/s12935-018-0596-x Text en © The Author(s) 2018 Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.
spellingShingle Review
Wang, Hairong
Liu, Shiming
Jia, Li
Chu, Fengyun
Zhou, Ya
He, Zhixu
Guo, Mengmeng
Chen, Chao
Xu, Lin
Nanostructured lipid carriers for MicroRNA delivery in tumor gene therapy
title Nanostructured lipid carriers for MicroRNA delivery in tumor gene therapy
title_full Nanostructured lipid carriers for MicroRNA delivery in tumor gene therapy
title_fullStr Nanostructured lipid carriers for MicroRNA delivery in tumor gene therapy
title_full_unstemmed Nanostructured lipid carriers for MicroRNA delivery in tumor gene therapy
title_short Nanostructured lipid carriers for MicroRNA delivery in tumor gene therapy
title_sort nanostructured lipid carriers for microrna delivery in tumor gene therapy
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6043968/
https://www.ncbi.nlm.nih.gov/pubmed/30008618
http://dx.doi.org/10.1186/s12935-018-0596-x
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