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The controversial role of Enterococcus faecalis in colorectal cancer

Colorectal cancer (CRC) is a complex and widespread disease, currently ranked as the third most frequent cancer worldwide. It is well known that the gut microbiota has an essential role in the initiation and promotion of different cancer types, particularly gastrointestinal tumors. In fact, bacteria...

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Detalles Bibliográficos
Autores principales: de Almeida, Carolina Vieira, Taddei, Antonio, Amedei, Amedeo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: SAGE Publications 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6044108/
https://www.ncbi.nlm.nih.gov/pubmed/30013618
http://dx.doi.org/10.1177/1756284818783606
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author de Almeida, Carolina Vieira
Taddei, Antonio
Amedei, Amedeo
author_facet de Almeida, Carolina Vieira
Taddei, Antonio
Amedei, Amedeo
author_sort de Almeida, Carolina Vieira
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description Colorectal cancer (CRC) is a complex and widespread disease, currently ranked as the third most frequent cancer worldwide. It is well known that the gut microbiota has an essential role in the initiation and promotion of different cancer types, particularly gastrointestinal tumors. In fact, bacteria can trigger chronic inflammation of the gastric mucosal, which can induce irreversible changes to intestinal epithelial cells, thus predisposing individuals to cancer. Some bacterial strains, such as Helicobacter pylori, Streptococcus bovis, Bacteroides fragilis, Clostridium septicum and Fusobacterium spp. have a well established role in CRC development. However, the role of Enterococcus faecalis still remains controversial. While part of the literature suggests a harmful role, other papers reported E. faecalis as an important probiotic microorganism, with great applicability in food products. In this review we have examined the vast majority of published data about E. faecalis either in CRC development or concerning its protective role. Our analysis should provide some answers regarding the controversial role of E. faecalis in CRC.
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spelling pubmed-60441082018-07-16 The controversial role of Enterococcus faecalis in colorectal cancer de Almeida, Carolina Vieira Taddei, Antonio Amedei, Amedeo Therap Adv Gastroenterol Review Colorectal cancer (CRC) is a complex and widespread disease, currently ranked as the third most frequent cancer worldwide. It is well known that the gut microbiota has an essential role in the initiation and promotion of different cancer types, particularly gastrointestinal tumors. In fact, bacteria can trigger chronic inflammation of the gastric mucosal, which can induce irreversible changes to intestinal epithelial cells, thus predisposing individuals to cancer. Some bacterial strains, such as Helicobacter pylori, Streptococcus bovis, Bacteroides fragilis, Clostridium septicum and Fusobacterium spp. have a well established role in CRC development. However, the role of Enterococcus faecalis still remains controversial. While part of the literature suggests a harmful role, other papers reported E. faecalis as an important probiotic microorganism, with great applicability in food products. In this review we have examined the vast majority of published data about E. faecalis either in CRC development or concerning its protective role. Our analysis should provide some answers regarding the controversial role of E. faecalis in CRC. SAGE Publications 2018-06-26 /pmc/articles/PMC6044108/ /pubmed/30013618 http://dx.doi.org/10.1177/1756284818783606 Text en © The Author(s), 2018 http://www.creativecommons.org/licenses/by-nc/4.0/ This article is distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 License (http://www.creativecommons.org/licenses/by-nc/4.0/) which permits non-commercial use, reproduction and distribution of the work without further permission provided the original work is attributed as specified on the SAGE and Open Access pages (https://us.sagepub.com/en-us/nam/open-access-at-sage).
spellingShingle Review
de Almeida, Carolina Vieira
Taddei, Antonio
Amedei, Amedeo
The controversial role of Enterococcus faecalis in colorectal cancer
title The controversial role of Enterococcus faecalis in colorectal cancer
title_full The controversial role of Enterococcus faecalis in colorectal cancer
title_fullStr The controversial role of Enterococcus faecalis in colorectal cancer
title_full_unstemmed The controversial role of Enterococcus faecalis in colorectal cancer
title_short The controversial role of Enterococcus faecalis in colorectal cancer
title_sort controversial role of enterococcus faecalis in colorectal cancer
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6044108/
https://www.ncbi.nlm.nih.gov/pubmed/30013618
http://dx.doi.org/10.1177/1756284818783606
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