Cargando…

ANIMAL MODELS FOR COLORECTAL CANCER

INTRODUCTION: Colorectal cancer is a very frequent sort of neoplasm among the population, with a high mortality rate. It develops from an association of genetic and environmental factors, and it is related to multiple cell signaling pathways. Cell cultures and animal models are used in research to r...

Descripción completa

Detalles Bibliográficos
Autores principales: DE-SOUZA, Alana Serrano Campelo, COSTA-CASAGRANDE, Thais Andrade
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Colégio Brasileiro de Cirurgia Digestiva 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6044195/
https://www.ncbi.nlm.nih.gov/pubmed/29972397
http://dx.doi.org/10.1590/0102-672020180001e1369
_version_ 1783339436678840320
author DE-SOUZA, Alana Serrano Campelo
COSTA-CASAGRANDE, Thais Andrade
author_facet DE-SOUZA, Alana Serrano Campelo
COSTA-CASAGRANDE, Thais Andrade
author_sort DE-SOUZA, Alana Serrano Campelo
collection PubMed
description INTRODUCTION: Colorectal cancer is a very frequent sort of neoplasm among the population, with a high mortality rate. It develops from an association of genetic and environmental factors, and it is related to multiple cell signaling pathways. Cell cultures and animal models are used in research to reproduce the process of disease development in humans. Of the existing animal models, the most commonly used are animals with tumors induced by chemical agents and genetically modified animals. OBJECTIVE: To present and synthesize the main animal models of colorectal carcinogenesis used in the research, comparing its advantages and disadvantages. METHOD: This literature review was performed through the search for scientific articles over the last 18 years in PubMed and Science Direct databases, by using keywords such as “animal models”, “colorectal carcinogenesis” and “tumor induction”. RESULTS: 1,2-dimethylhydrazine and azoxymethane are carcinogenic agents with high specificity for the small and large intestine regions. Therefore, the two substances are widely used. Concerning the genetically modified animal models, there is a larger number of studies concerning mutations of the APC, p53 and K-ras genes. Animals with the APC gene mutation develop colorectal neoplasms, whereas animals with p53 and K-ras genes mutations are able to potentiate the effects of the APC gene mutation as well as the chemical inducers. CONCLUSION: Each animal model has advantages and disadvantages, and some are individually efficient as to the induction of carcinogenesis, and in other cases the association of two forms of induction is the best way to obtain representative results of carcinogenesis in humans.
format Online
Article
Text
id pubmed-6044195
institution National Center for Biotechnology Information
language English
publishDate 2018
publisher Colégio Brasileiro de Cirurgia Digestiva
record_format MEDLINE/PubMed
spelling pubmed-60441952018-07-16 ANIMAL MODELS FOR COLORECTAL CANCER DE-SOUZA, Alana Serrano Campelo COSTA-CASAGRANDE, Thais Andrade Arq Bras Cir Dig Review Article INTRODUCTION: Colorectal cancer is a very frequent sort of neoplasm among the population, with a high mortality rate. It develops from an association of genetic and environmental factors, and it is related to multiple cell signaling pathways. Cell cultures and animal models are used in research to reproduce the process of disease development in humans. Of the existing animal models, the most commonly used are animals with tumors induced by chemical agents and genetically modified animals. OBJECTIVE: To present and synthesize the main animal models of colorectal carcinogenesis used in the research, comparing its advantages and disadvantages. METHOD: This literature review was performed through the search for scientific articles over the last 18 years in PubMed and Science Direct databases, by using keywords such as “animal models”, “colorectal carcinogenesis” and “tumor induction”. RESULTS: 1,2-dimethylhydrazine and azoxymethane are carcinogenic agents with high specificity for the small and large intestine regions. Therefore, the two substances are widely used. Concerning the genetically modified animal models, there is a larger number of studies concerning mutations of the APC, p53 and K-ras genes. Animals with the APC gene mutation develop colorectal neoplasms, whereas animals with p53 and K-ras genes mutations are able to potentiate the effects of the APC gene mutation as well as the chemical inducers. CONCLUSION: Each animal model has advantages and disadvantages, and some are individually efficient as to the induction of carcinogenesis, and in other cases the association of two forms of induction is the best way to obtain representative results of carcinogenesis in humans. Colégio Brasileiro de Cirurgia Digestiva 2018-07-02 /pmc/articles/PMC6044195/ /pubmed/29972397 http://dx.doi.org/10.1590/0102-672020180001e1369 Text en https://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License
spellingShingle Review Article
DE-SOUZA, Alana Serrano Campelo
COSTA-CASAGRANDE, Thais Andrade
ANIMAL MODELS FOR COLORECTAL CANCER
title ANIMAL MODELS FOR COLORECTAL CANCER
title_full ANIMAL MODELS FOR COLORECTAL CANCER
title_fullStr ANIMAL MODELS FOR COLORECTAL CANCER
title_full_unstemmed ANIMAL MODELS FOR COLORECTAL CANCER
title_short ANIMAL MODELS FOR COLORECTAL CANCER
title_sort animal models for colorectal cancer
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6044195/
https://www.ncbi.nlm.nih.gov/pubmed/29972397
http://dx.doi.org/10.1590/0102-672020180001e1369
work_keys_str_mv AT desouzaalanaserranocampelo animalmodelsforcolorectalcancer
AT costacasagrandethaisandrade animalmodelsforcolorectalcancer