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CURRENT STATUS OF THE MULTIDISCIPLINARY TREATMENT OF GASTRIC ADENOCARCINOMA

BACKGROUND: The complexity of the management of gastric cancer requires a multidisciplinary evaluation of patients with this tumor. Several treatments have been employed, associated to the surgical resection. OBJECTIVE: To review the available therapeutic alternatives for the treatment of gastric ad...

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Detalles Bibliográficos
Autores principales: TONETO, Marcelo Garcia, VIOLA, Luciana
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Colégio Brasileiro de Cirurgia Digestiva 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6044205/
https://www.ncbi.nlm.nih.gov/pubmed/29972401
http://dx.doi.org/10.1590/0102-672020180001e1373
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author TONETO, Marcelo Garcia
VIOLA, Luciana
author_facet TONETO, Marcelo Garcia
VIOLA, Luciana
author_sort TONETO, Marcelo Garcia
collection PubMed
description BACKGROUND: The complexity of the management of gastric cancer requires a multidisciplinary evaluation of patients with this tumor. Several treatments have been employed, associated to the surgical resection. OBJECTIVE: To review the available therapeutic alternatives for the treatment of gastric adenocarcinoma. METHODS : A review of selected articles on multidisciplinary treatment of gastric adenocarcinoma in the Pubmed and Medline databases between 2000 and 2017 was carried out. The following headings were related: stomach cancer, treatment, chemotherapy and radiotherapy. RESULTS : There are several valid alternatives, with good results for the treatment of gastric cancer: chemoradiotherapy or chemotherapy in the adjuvant scenario; perioperative chemotherapy; and chemoradiotherapy after neoadjuvance with isolated chemotherapy. CONCLUSION : Current evidences suggest that combined multidisciplinary treatment is superior to surgery alone. However, the optimal treatment regimen is not yet established, and depends on a number of factors, especially the type of surgical resection employed. Therefore, the therapeutic decision should be made by a multidisciplinary team, assessing patient’s personal characteristics, biology of the tumor, residual disease, risks and side effects.
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spelling pubmed-60442052018-07-16 CURRENT STATUS OF THE MULTIDISCIPLINARY TREATMENT OF GASTRIC ADENOCARCINOMA TONETO, Marcelo Garcia VIOLA, Luciana Arq Bras Cir Dig Review Article BACKGROUND: The complexity of the management of gastric cancer requires a multidisciplinary evaluation of patients with this tumor. Several treatments have been employed, associated to the surgical resection. OBJECTIVE: To review the available therapeutic alternatives for the treatment of gastric adenocarcinoma. METHODS : A review of selected articles on multidisciplinary treatment of gastric adenocarcinoma in the Pubmed and Medline databases between 2000 and 2017 was carried out. The following headings were related: stomach cancer, treatment, chemotherapy and radiotherapy. RESULTS : There are several valid alternatives, with good results for the treatment of gastric cancer: chemoradiotherapy or chemotherapy in the adjuvant scenario; perioperative chemotherapy; and chemoradiotherapy after neoadjuvance with isolated chemotherapy. CONCLUSION : Current evidences suggest that combined multidisciplinary treatment is superior to surgery alone. However, the optimal treatment regimen is not yet established, and depends on a number of factors, especially the type of surgical resection employed. Therefore, the therapeutic decision should be made by a multidisciplinary team, assessing patient’s personal characteristics, biology of the tumor, residual disease, risks and side effects. Colégio Brasileiro de Cirurgia Digestiva 2018-07-02 /pmc/articles/PMC6044205/ /pubmed/29972401 http://dx.doi.org/10.1590/0102-672020180001e1373 Text en https://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License
spellingShingle Review Article
TONETO, Marcelo Garcia
VIOLA, Luciana
CURRENT STATUS OF THE MULTIDISCIPLINARY TREATMENT OF GASTRIC ADENOCARCINOMA
title CURRENT STATUS OF THE MULTIDISCIPLINARY TREATMENT OF GASTRIC ADENOCARCINOMA
title_full CURRENT STATUS OF THE MULTIDISCIPLINARY TREATMENT OF GASTRIC ADENOCARCINOMA
title_fullStr CURRENT STATUS OF THE MULTIDISCIPLINARY TREATMENT OF GASTRIC ADENOCARCINOMA
title_full_unstemmed CURRENT STATUS OF THE MULTIDISCIPLINARY TREATMENT OF GASTRIC ADENOCARCINOMA
title_short CURRENT STATUS OF THE MULTIDISCIPLINARY TREATMENT OF GASTRIC ADENOCARCINOMA
title_sort current status of the multidisciplinary treatment of gastric adenocarcinoma
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6044205/
https://www.ncbi.nlm.nih.gov/pubmed/29972401
http://dx.doi.org/10.1590/0102-672020180001e1373
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