Cooperative Domain Formation by Homologous Motifs in HOIL-1L and SHARPIN Plays A Crucial Role in LUBAC Stabilization

The linear ubiquitin chain assembly complex (LUBAC) participates in inflammatory and oncogenic signaling by conjugating linear ubiquitin chains to target proteins. LUBAC consists of the catalytic HOIP subunit and two accessory subunits, HOIL-1L and SHARPIN. Interactions between the ubiquitin-associa...

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Detalles Bibliográficos
Autores principales: Fujita, Hiroaki, Tokunaga, Akira, Shimizu, Satoshi, Whiting, Amanda L., Aguilar-Alonso, Francisco, Takagi, Kenji, Walinda, Erik, Sasaki, Yoshiteru, Shimokawa, Taketo, Mizushima, Tsunehiro, Ohki, Izuru, Ariyoshi, Mariko, Tochio, Hidehito, Bernal, Federico, Shirakawa, Masahiro, Iwai, Kazuhiro
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6044281/
https://www.ncbi.nlm.nih.gov/pubmed/29694895
http://dx.doi.org/10.1016/j.celrep.2018.03.112

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