PARP1-Erk synergism in proliferating cells

A synergism between PARP1 and phosphorylated Erk mediating IEG (immediate early gene) expression has been recently reported in cerebral neurons and cardiomyocytes. Stimulation induced PARP-Erk synergism was required for IEG expression underlying synaptic plasticity and long-term memory acquisition d...

Descripción completa

Detalles Bibliográficos
Autores principales: Visochek, Leonid, Cohen-Armon, Malka
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2018
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6044375/
https://www.ncbi.nlm.nih.gov/pubmed/30018741
http://dx.doi.org/10.18632/oncotarget.25633
_version_ 1783339471570206720
author Visochek, Leonid
Cohen-Armon, Malka
author_facet Visochek, Leonid
Cohen-Armon, Malka
author_sort Visochek, Leonid
collection PubMed
description A synergism between PARP1 and phosphorylated Erk mediating IEG (immediate early gene) expression has been recently reported in cerebral neurons and cardiomyocytes. Stimulation induced PARP-Erk synergism was required for IEG expression underlying synaptic plasticity and long-term memory acquisition during learning. It was similarly required for cardiomyocytes development. Here, we identified this mechanism in Erk-induced gene expression promoting proliferation. This mechanism can be targeted in malignant cells.
format Online
Article
Text
id pubmed-6044375
institution National Center for Biotechnology Information
language English
publishDate 2018
publisher Impact Journals LLC
record_format MEDLINE/PubMed
spelling pubmed-60443752018-07-17 PARP1-Erk synergism in proliferating cells Visochek, Leonid Cohen-Armon, Malka Oncotarget Research Paper A synergism between PARP1 and phosphorylated Erk mediating IEG (immediate early gene) expression has been recently reported in cerebral neurons and cardiomyocytes. Stimulation induced PARP-Erk synergism was required for IEG expression underlying synaptic plasticity and long-term memory acquisition during learning. It was similarly required for cardiomyocytes development. Here, we identified this mechanism in Erk-induced gene expression promoting proliferation. This mechanism can be targeted in malignant cells. Impact Journals LLC 2018-06-26 /pmc/articles/PMC6044375/ /pubmed/30018741 http://dx.doi.org/10.18632/oncotarget.25633 Text en Copyright: © 2018 Visochek et al. http://creativecommons.org/licenses/by/3.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0/) 3.0 (CC BY 3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Research Paper
Visochek, Leonid
Cohen-Armon, Malka
PARP1-Erk synergism in proliferating cells
title PARP1-Erk synergism in proliferating cells
title_full PARP1-Erk synergism in proliferating cells
title_fullStr PARP1-Erk synergism in proliferating cells
title_full_unstemmed PARP1-Erk synergism in proliferating cells
title_short PARP1-Erk synergism in proliferating cells
title_sort parp1-erk synergism in proliferating cells
topic Research Paper
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6044375/
https://www.ncbi.nlm.nih.gov/pubmed/30018741
http://dx.doi.org/10.18632/oncotarget.25633
work_keys_str_mv AT visochekleonid parp1erksynergisminproliferatingcells
AT cohenarmonmalka parp1erksynergisminproliferatingcells

Ejemplares similares