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Structure of the Cdc48 ATPase with its ubiquitin-binding cofactor Ufd1-Npl4
Many poly-ubiquitinated proteins are extracted from membranes or complexes by a conserved ATPase, called Cdc48 in yeast and p97/VCP in mammals, before proteasomal degradation(1). Each Cdc48 hexamer contains two stacked ATPase rings (D1 and D2) and six N-terminal (N) domains(2). Cdc48 binds various c...
| Autores principales: | , , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
2018
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6044470/ https://www.ncbi.nlm.nih.gov/pubmed/29967539 http://dx.doi.org/10.1038/s41594-018-0085-x |