Mutant GNAS drives pancreatic tumorigenesis by inducing PKA-mediated SIK suppression and reprogramming lipid metabolism

G-protein α(s) (GNAS) mediates receptor-stimulated cAMP signaling, which integrates diverse environmental cues with intracellular responses. GNAS is mutationally activated in multiple tumor types, although its oncogenic mechanisms remain elusive. We explored this question in pancreatic tumorigenesis...

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Detalles Bibliográficos
Autores principales: Patra, Krushna C., Kato, Yasutaka, Mizukami, Yusuke, Widholz, Sebastian, Boukhali, Myriam, Revenco, Iulia, Grossman, Elizabeth A., Ji, Fei, Sadreyev, Ruslan I., Liss, Andrew S., Screaton, Robert A., Sakamoto, Kei, Ryan, David P., Mino-Kenudson, Mari, Castillo, Carlos Fernandez-del, Nomura, Daniel K., Haas, Wilhelm, Bardeesy, Nabeel
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6044476/
https://www.ncbi.nlm.nih.gov/pubmed/29941929
http://dx.doi.org/10.1038/s41556-018-0122-3

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