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pH plays a role in the mode of action of trimethoprim on Escherichia coli

Metabolomics-based approaches were applied to understand interactions of trimethoprim with Escherichia coli K-12 at sub-minimum inhibitory concentrations (MIC≈0.2, 0.03 and 0.003 mg L(-1)). Trimethoprim inhibits dihydrofolate reductase and thereby is an indirect inhibitor of nucleic acid synthesis....

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Detalles Bibliográficos
Autores principales: AlRabiah, Haitham, Allwood, J. William, Correa, Elon, Xu, Yun, Goodacre, Royston
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6044521/
https://www.ncbi.nlm.nih.gov/pubmed/30005078
http://dx.doi.org/10.1371/journal.pone.0200272