Epidermal growth factor receptor inhibition with Gefitinib does not alter lung responses to mechanical ventilation in fetal, preterm lambs

BACKGROUND: Epidermal growth factor receptor (EGFR) is important for airway branching and lung maturation. Mechanical ventilation of preterm lambs causes increases in EGFR and EGFR ligand mRNA in the lung. Abnormal EGFR signaling may contribute to the development of bronchopulmonary dysplasia. HYPOT...

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Detalles Bibliográficos
Autores principales: Kothe, T. Brett, Royse, Emily, Kemp, Matthew W., Usuda, Haruo, Saito, Masatoshi, Musk, Gabrielle C., Jobe, Alan H., Hillman, Noah H.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2018
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6044532/
https://www.ncbi.nlm.nih.gov/pubmed/30005089
http://dx.doi.org/10.1371/journal.pone.0200713

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