BBB: Permeable Conjugate of Exogenic GABA

[Image: see text] Neurotransmitters are the key factors in ameliorating the symptoms of nervous system diseases. Stroke/cerebral ischemia has been proven to be caused by the excess release of excitatory amino acid glutamate in the brain, and the inhibitory neurotransmitter γ-aminobutyric acid (GABA)...

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Autores principales: Li, Qian, Wang, Shuhao, Xiao, Weibin, Huang, Chunqian, Li, Hua, Sun, Manji
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2017
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6044556/
https://www.ncbi.nlm.nih.gov/pubmed/30023712
http://dx.doi.org/10.1021/acsomega.7b00425
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author Li, Qian
Wang, Shuhao
Xiao, Weibin
Huang, Chunqian
Li, Hua
Sun, Manji
author_facet Li, Qian
Wang, Shuhao
Xiao, Weibin
Huang, Chunqian
Li, Hua
Sun, Manji
author_sort Li, Qian
collection PubMed
description [Image: see text] Neurotransmitters are the key factors in ameliorating the symptoms of nervous system diseases. Stroke/cerebral ischemia has been proven to be caused by the excess release of excitatory amino acid glutamate in the brain, and the inhibitory neurotransmitter γ-aminobutyric acid (GABA) is considered to be the best choice to counteract the action of glutamate. Here, we show that GABA conjugated to a cytoplasmic transduction peptide (YGRRARRRRRR) by means of custom chemical synthesis could penetrate through the blood–brain barrier, increasing the GABA level in the plasma of rats and mice, which, as a result, display a state of calmness and somnolence.
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spelling pubmed-60445562018-07-16 BBB: Permeable Conjugate of Exogenic GABA Li, Qian Wang, Shuhao Xiao, Weibin Huang, Chunqian Li, Hua Sun, Manji ACS Omega [Image: see text] Neurotransmitters are the key factors in ameliorating the symptoms of nervous system diseases. Stroke/cerebral ischemia has been proven to be caused by the excess release of excitatory amino acid glutamate in the brain, and the inhibitory neurotransmitter γ-aminobutyric acid (GABA) is considered to be the best choice to counteract the action of glutamate. Here, we show that GABA conjugated to a cytoplasmic transduction peptide (YGRRARRRRRR) by means of custom chemical synthesis could penetrate through the blood–brain barrier, increasing the GABA level in the plasma of rats and mice, which, as a result, display a state of calmness and somnolence. American Chemical Society 2017-08-01 /pmc/articles/PMC6044556/ /pubmed/30023712 http://dx.doi.org/10.1021/acsomega.7b00425 Text en Copyright © 2017 American Chemical Society This is an open access article published under an ACS AuthorChoice License (http://pubs.acs.org/page/policy/authorchoice_termsofuse.html) , which permits copying and redistribution of the article or any adaptations for non-commercial purposes.
spellingShingle Li, Qian
Wang, Shuhao
Xiao, Weibin
Huang, Chunqian
Li, Hua
Sun, Manji
BBB: Permeable Conjugate of Exogenic GABA
title BBB: Permeable Conjugate of Exogenic GABA
title_full BBB: Permeable Conjugate of Exogenic GABA
title_fullStr BBB: Permeable Conjugate of Exogenic GABA
title_full_unstemmed BBB: Permeable Conjugate of Exogenic GABA
title_short BBB: Permeable Conjugate of Exogenic GABA
title_sort bbb: permeable conjugate of exogenic gaba
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6044556/
https://www.ncbi.nlm.nih.gov/pubmed/30023712
http://dx.doi.org/10.1021/acsomega.7b00425
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