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Biodegradable and Bioactive PCL–PGS Core–Shell Fibers for Tissue Engineering
[Image: see text] Poly(glycerol sebacate) (PGS) has increasingly become a desirable biomaterial due to its elastic mechanical properties, biodegradability, and biocompatibility. Here, we report microfibrous core–shell mats of polycaprolactone (PCL)–PGS prepared using wet–wet coaxial electrospinning....
Autores principales: | , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
American Chemical Society
2017
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6044571/ https://www.ncbi.nlm.nih.gov/pubmed/30023516 http://dx.doi.org/10.1021/acsomega.7b00460 |
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author | Hou, Lijuan Zhang, Xing Mikael, Paiyz E. Lin, Lei Dong, Wenjun Zheng, Yingying Simmons, Trevor John Zhang, Fuming Linhardt, Robert J. |
author_facet | Hou, Lijuan Zhang, Xing Mikael, Paiyz E. Lin, Lei Dong, Wenjun Zheng, Yingying Simmons, Trevor John Zhang, Fuming Linhardt, Robert J. |
author_sort | Hou, Lijuan |
collection | PubMed |
description | [Image: see text] Poly(glycerol sebacate) (PGS) has increasingly become a desirable biomaterial due to its elastic mechanical properties, biodegradability, and biocompatibility. Here, we report microfibrous core–shell mats of polycaprolactone (PCL)–PGS prepared using wet–wet coaxial electrospinning. The anticoagulant heparin was immobilized onto the surface of these electrospun fiber mats, and they were evaluated for their chemical, mechanical, and biological properties. The core–shell structure of PCL–PGS provided tunable degradation and mechanical properties. The slowly degrading PCL provided structural integrity, and the fast degrading PGS component increased fiber elasticity. Young’s modulus of PCL–PGS ranged from 5.6 to 15.7 MPa. The ultimate tensile stress ranged from 2.0 to 2.9 MPa, and these fibers showed elongation from 290 to 900%. The addition of PGS and grafting of heparin improved the attachment and proliferation of human umbilical vein endothelial cells. Core–shell PCL–PGS fibers demonstrate improved performance as three-dimensional fibrous mats for potential tissue-engineering applications. |
format | Online Article Text |
id | pubmed-6044571 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2017 |
publisher | American Chemical Society |
record_format | MEDLINE/PubMed |
spelling | pubmed-60445712018-07-16 Biodegradable and Bioactive PCL–PGS Core–Shell Fibers for Tissue Engineering Hou, Lijuan Zhang, Xing Mikael, Paiyz E. Lin, Lei Dong, Wenjun Zheng, Yingying Simmons, Trevor John Zhang, Fuming Linhardt, Robert J. ACS Omega [Image: see text] Poly(glycerol sebacate) (PGS) has increasingly become a desirable biomaterial due to its elastic mechanical properties, biodegradability, and biocompatibility. Here, we report microfibrous core–shell mats of polycaprolactone (PCL)–PGS prepared using wet–wet coaxial electrospinning. The anticoagulant heparin was immobilized onto the surface of these electrospun fiber mats, and they were evaluated for their chemical, mechanical, and biological properties. The core–shell structure of PCL–PGS provided tunable degradation and mechanical properties. The slowly degrading PCL provided structural integrity, and the fast degrading PGS component increased fiber elasticity. Young’s modulus of PCL–PGS ranged from 5.6 to 15.7 MPa. The ultimate tensile stress ranged from 2.0 to 2.9 MPa, and these fibers showed elongation from 290 to 900%. The addition of PGS and grafting of heparin improved the attachment and proliferation of human umbilical vein endothelial cells. Core–shell PCL–PGS fibers demonstrate improved performance as three-dimensional fibrous mats for potential tissue-engineering applications. American Chemical Society 2017-10-02 /pmc/articles/PMC6044571/ /pubmed/30023516 http://dx.doi.org/10.1021/acsomega.7b00460 Text en Copyright © 2017 American Chemical Society This is an open access article published under an ACS AuthorChoice License (http://pubs.acs.org/page/policy/authorchoice_termsofuse.html) , which permits copying and redistribution of the article or any adaptations for non-commercial purposes. |
spellingShingle | Hou, Lijuan Zhang, Xing Mikael, Paiyz E. Lin, Lei Dong, Wenjun Zheng, Yingying Simmons, Trevor John Zhang, Fuming Linhardt, Robert J. Biodegradable and Bioactive PCL–PGS Core–Shell Fibers for Tissue Engineering |
title | Biodegradable and Bioactive PCL–PGS Core–Shell
Fibers for Tissue Engineering |
title_full | Biodegradable and Bioactive PCL–PGS Core–Shell
Fibers for Tissue Engineering |
title_fullStr | Biodegradable and Bioactive PCL–PGS Core–Shell
Fibers for Tissue Engineering |
title_full_unstemmed | Biodegradable and Bioactive PCL–PGS Core–Shell
Fibers for Tissue Engineering |
title_short | Biodegradable and Bioactive PCL–PGS Core–Shell
Fibers for Tissue Engineering |
title_sort | biodegradable and bioactive pcl–pgs core–shell
fibers for tissue engineering |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6044571/ https://www.ncbi.nlm.nih.gov/pubmed/30023516 http://dx.doi.org/10.1021/acsomega.7b00460 |
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