Cargando…
Folding Kinetics of Single Human Telomeric G-Quadruplex Affected by Cisplatin
[Image: see text] G-Quadruplex DNA structure has been proven to be a binding target for small molecular organic compounds and hence regarded as a promising pharmacological target. Cisplatin is a widely used chemotherapy drug that targets duplex DNA and was recently shown to react also with G-quadrup...
Autores principales: | , , , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
American Chemical Society
2016
|
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6044606/ https://www.ncbi.nlm.nih.gov/pubmed/30023477 http://dx.doi.org/10.1021/acsomega.6b00044 |
_version_ | 1783339502357446656 |
---|---|
author | Ju, Hai-Peng Wang, Yi-Zhou You, Jing Hou, Xi-Miao Xi, Xu-Guang Dou, Shuo-Xing Li, Wei Wang, Peng-Ye |
author_facet | Ju, Hai-Peng Wang, Yi-Zhou You, Jing Hou, Xi-Miao Xi, Xu-Guang Dou, Shuo-Xing Li, Wei Wang, Peng-Ye |
author_sort | Ju, Hai-Peng |
collection | PubMed |
description | [Image: see text] G-Quadruplex DNA structure has been proven to be a binding target for small molecular organic compounds and hence regarded as a promising pharmacological target. Cisplatin is a widely used chemotherapy drug that targets duplex DNA and was recently shown to react also with G-quadruplex, implying that cisplatin actually may also target G-quadruplex. In this work, we employed magnetic tweezers to investigate the influence of cisplatin on the folding kinetics of single human telomeric G-quadruplex. It was revealed that cisplatin and G-quadruplex interact in two different and competitive ways that depend on cisplatin concentration. |
format | Online Article Text |
id | pubmed-6044606 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2016 |
publisher | American Chemical Society |
record_format | MEDLINE/PubMed |
spelling | pubmed-60446062018-07-16 Folding Kinetics of Single Human Telomeric G-Quadruplex Affected by Cisplatin Ju, Hai-Peng Wang, Yi-Zhou You, Jing Hou, Xi-Miao Xi, Xu-Guang Dou, Shuo-Xing Li, Wei Wang, Peng-Ye ACS Omega [Image: see text] G-Quadruplex DNA structure has been proven to be a binding target for small molecular organic compounds and hence regarded as a promising pharmacological target. Cisplatin is a widely used chemotherapy drug that targets duplex DNA and was recently shown to react also with G-quadruplex, implying that cisplatin actually may also target G-quadruplex. In this work, we employed magnetic tweezers to investigate the influence of cisplatin on the folding kinetics of single human telomeric G-quadruplex. It was revealed that cisplatin and G-quadruplex interact in two different and competitive ways that depend on cisplatin concentration. American Chemical Society 2016-08-24 /pmc/articles/PMC6044606/ /pubmed/30023477 http://dx.doi.org/10.1021/acsomega.6b00044 Text en Copyright © 2016 American Chemical Society This is an open access article published under an ACS AuthorChoice License (http://pubs.acs.org/page/policy/authorchoice_termsofuse.html) , which permits copying and redistribution of the article or any adaptations for non-commercial purposes. |
spellingShingle | Ju, Hai-Peng Wang, Yi-Zhou You, Jing Hou, Xi-Miao Xi, Xu-Guang Dou, Shuo-Xing Li, Wei Wang, Peng-Ye Folding Kinetics of Single Human Telomeric G-Quadruplex Affected by Cisplatin |
title | Folding Kinetics of Single Human Telomeric G-Quadruplex
Affected by Cisplatin |
title_full | Folding Kinetics of Single Human Telomeric G-Quadruplex
Affected by Cisplatin |
title_fullStr | Folding Kinetics of Single Human Telomeric G-Quadruplex
Affected by Cisplatin |
title_full_unstemmed | Folding Kinetics of Single Human Telomeric G-Quadruplex
Affected by Cisplatin |
title_short | Folding Kinetics of Single Human Telomeric G-Quadruplex
Affected by Cisplatin |
title_sort | folding kinetics of single human telomeric g-quadruplex
affected by cisplatin |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6044606/ https://www.ncbi.nlm.nih.gov/pubmed/30023477 http://dx.doi.org/10.1021/acsomega.6b00044 |
work_keys_str_mv | AT juhaipeng foldingkineticsofsinglehumantelomericgquadruplexaffectedbycisplatin AT wangyizhou foldingkineticsofsinglehumantelomericgquadruplexaffectedbycisplatin AT youjing foldingkineticsofsinglehumantelomericgquadruplexaffectedbycisplatin AT houximiao foldingkineticsofsinglehumantelomericgquadruplexaffectedbycisplatin AT xixuguang foldingkineticsofsinglehumantelomericgquadruplexaffectedbycisplatin AT doushuoxing foldingkineticsofsinglehumantelomericgquadruplexaffectedbycisplatin AT liwei foldingkineticsofsinglehumantelomericgquadruplexaffectedbycisplatin AT wangpengye foldingkineticsofsinglehumantelomericgquadruplexaffectedbycisplatin |