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Chemical Profiling of Medical Cannabis Extracts
[Image: see text] Medical cannabis has been legally available for patients in a number of countries. Licensed producers produce a variety of cannabis strains with different concentrations of phytocannabinoids. Phytocannabinoids in medical cannabis are decarboxylated when subjected to heating for con...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
American
Chemical
Society
2017
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6044620/ https://www.ncbi.nlm.nih.gov/pubmed/30023762 http://dx.doi.org/10.1021/acsomega.7b00996 |
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author | Lewis, Melissa M. Yang, Yi Wasilewski, Ewa Clarke, Hance A. Kotra, Lakshmi P. |
author_facet | Lewis, Melissa M. Yang, Yi Wasilewski, Ewa Clarke, Hance A. Kotra, Lakshmi P. |
author_sort | Lewis, Melissa M. |
collection | PubMed |
description | [Image: see text] Medical cannabis has been legally available for patients in a number of countries. Licensed producers produce a variety of cannabis strains with different concentrations of phytocannabinoids. Phytocannabinoids in medical cannabis are decarboxylated when subjected to heating for consumption by the patients or when extracted for preparing cannabis derivative products. There is little understanding of the true chemical composition of cannabis extracts, changes occurring during heating of the extracts, and their relevance to pharmacological effects. We investigated the extract from a popular commercial strain of medical cannabis, prior to and after decarboxylation, to understand the chemical profiles. A total of up to 62 compounds could be identified simultaneously in the extract derived from commercial cannabis, including up to 23 phytocannabinoids. Upon heating, several chemical changes take place, including the loss of carboxylic group from the acidic phytocannabinoids. This investigation attempts to reveal the chemical complexity of commercial medical cannabis extracts and the differences in the chemical composition of the native extract and the one subjected to heat. Comprehensive chemical analyses of medical cannabis extracts are needed for standardization, consistency, and, more importantly, an informed employment of this substance for therapeutic purposes. |
format | Online Article Text |
id | pubmed-6044620 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2017 |
publisher | American
Chemical
Society |
record_format | MEDLINE/PubMed |
spelling | pubmed-60446202018-07-16 Chemical Profiling of Medical Cannabis Extracts Lewis, Melissa M. Yang, Yi Wasilewski, Ewa Clarke, Hance A. Kotra, Lakshmi P. ACS Omega [Image: see text] Medical cannabis has been legally available for patients in a number of countries. Licensed producers produce a variety of cannabis strains with different concentrations of phytocannabinoids. Phytocannabinoids in medical cannabis are decarboxylated when subjected to heating for consumption by the patients or when extracted for preparing cannabis derivative products. There is little understanding of the true chemical composition of cannabis extracts, changes occurring during heating of the extracts, and their relevance to pharmacological effects. We investigated the extract from a popular commercial strain of medical cannabis, prior to and after decarboxylation, to understand the chemical profiles. A total of up to 62 compounds could be identified simultaneously in the extract derived from commercial cannabis, including up to 23 phytocannabinoids. Upon heating, several chemical changes take place, including the loss of carboxylic group from the acidic phytocannabinoids. This investigation attempts to reveal the chemical complexity of commercial medical cannabis extracts and the differences in the chemical composition of the native extract and the one subjected to heat. Comprehensive chemical analyses of medical cannabis extracts are needed for standardization, consistency, and, more importantly, an informed employment of this substance for therapeutic purposes. American Chemical Society 2017-09-22 /pmc/articles/PMC6044620/ /pubmed/30023762 http://dx.doi.org/10.1021/acsomega.7b00996 Text en Copyright © 2017 American Chemical Society This is an open access article published under an ACS AuthorChoice License (http://pubs.acs.org/page/policy/authorchoice_termsofuse.html) , which permits copying and redistribution of the article or any adaptations for non-commercial purposes. |
spellingShingle | Lewis, Melissa M. Yang, Yi Wasilewski, Ewa Clarke, Hance A. Kotra, Lakshmi P. Chemical Profiling of Medical Cannabis Extracts |
title | Chemical Profiling of Medical Cannabis Extracts |
title_full | Chemical Profiling of Medical Cannabis Extracts |
title_fullStr | Chemical Profiling of Medical Cannabis Extracts |
title_full_unstemmed | Chemical Profiling of Medical Cannabis Extracts |
title_short | Chemical Profiling of Medical Cannabis Extracts |
title_sort | chemical profiling of medical cannabis extracts |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6044620/ https://www.ncbi.nlm.nih.gov/pubmed/30023762 http://dx.doi.org/10.1021/acsomega.7b00996 |
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