Colloidal Polymeric Platform for Facile Click-Assisted Ligand Functionalization and Receptor Targeting

[Image: see text] Colloidal poly(glycidyl methacrylate) nanoparticles (NPs) are demonstrated to be platforms facilitating the “click” chemistry approach of surface functionalization for receptor targeting. Folate receptor-targeted NPs were synthesized, physicochemically characterized, confirmed for...

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Autores principales: Singh, Ruhani, Ho, Diwei, Lim, Lee Yong, Iyer, K. Swaminathan, Smith, Nicole M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2016
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6044634/
https://www.ncbi.nlm.nih.gov/pubmed/30023503
http://dx.doi.org/10.1021/acsomega.6b00239
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author Singh, Ruhani
Ho, Diwei
Lim, Lee Yong
Iyer, K. Swaminathan
Smith, Nicole M.
author_facet Singh, Ruhani
Ho, Diwei
Lim, Lee Yong
Iyer, K. Swaminathan
Smith, Nicole M.
author_sort Singh, Ruhani
collection PubMed
description [Image: see text] Colloidal poly(glycidyl methacrylate) nanoparticles (NPs) are demonstrated to be platforms facilitating the “click” chemistry approach of surface functionalization for receptor targeting. Folate receptor-targeted NPs were synthesized, physicochemically characterized, confirmed for their biocompatibility, and validated for their selective targeting capabilities for ovarian cancer cells in vitro.
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spelling pubmed-60446342018-07-16 Colloidal Polymeric Platform for Facile Click-Assisted Ligand Functionalization and Receptor Targeting Singh, Ruhani Ho, Diwei Lim, Lee Yong Iyer, K. Swaminathan Smith, Nicole M. ACS Omega [Image: see text] Colloidal poly(glycidyl methacrylate) nanoparticles (NPs) are demonstrated to be platforms facilitating the “click” chemistry approach of surface functionalization for receptor targeting. Folate receptor-targeted NPs were synthesized, physicochemically characterized, confirmed for their biocompatibility, and validated for their selective targeting capabilities for ovarian cancer cells in vitro. American Chemical Society 2016-12-06 /pmc/articles/PMC6044634/ /pubmed/30023503 http://dx.doi.org/10.1021/acsomega.6b00239 Text en Copyright © 2016 American Chemical Society This is an open access article published under an ACS AuthorChoice License (http://pubs.acs.org/page/policy/authorchoice_termsofuse.html) , which permits copying and redistribution of the article or any adaptations for non-commercial purposes.
spellingShingle Singh, Ruhani
Ho, Diwei
Lim, Lee Yong
Iyer, K. Swaminathan
Smith, Nicole M.
Colloidal Polymeric Platform for Facile Click-Assisted Ligand Functionalization and Receptor Targeting
title Colloidal Polymeric Platform for Facile Click-Assisted Ligand Functionalization and Receptor Targeting
title_full Colloidal Polymeric Platform for Facile Click-Assisted Ligand Functionalization and Receptor Targeting
title_fullStr Colloidal Polymeric Platform for Facile Click-Assisted Ligand Functionalization and Receptor Targeting
title_full_unstemmed Colloidal Polymeric Platform for Facile Click-Assisted Ligand Functionalization and Receptor Targeting
title_short Colloidal Polymeric Platform for Facile Click-Assisted Ligand Functionalization and Receptor Targeting
title_sort colloidal polymeric platform for facile click-assisted ligand functionalization and receptor targeting
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6044634/
https://www.ncbi.nlm.nih.gov/pubmed/30023503
http://dx.doi.org/10.1021/acsomega.6b00239
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