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Mechanistic Modeling of Reversed-Phase Chromatography of Insulins with Potassium Chloride and Ethanol as Mobile-Phase Modulators

[Image: see text] The purpose of this study was to investigate the adsorption mechanism in reversed-phase chromatography (RPC) of proteins and to develop a model for the effect of dual mobile phase modulators—a salt and an organic solvent—on this process. Two different adsorption mechanisms were con...

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Detalles Bibliográficos
Autores principales:	Arkell, Karolina, Breil, Martin P., Frederiksen, Søren S., Nilsson, Bernt
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Chemical Society 2017
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6044668/ https://www.ncbi.nlm.nih.gov/pubmed/30023511 http://dx.doi.org/10.1021/acsomega.6b00248

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