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Inhibition of DNA Methylation at the MLH1 Promoter Region Using Pyrrole–Imidazole Polyamide

[Image: see text] Aberrant DNA methylation causes major epigenetic changes and has been implicated in cancer following the inactivation of tumor suppressor genes by hypermethylation of promoter CpG islands. Although methylated DNA regions can be randomly demethylated by 5-azacytidine and 5-aza-2′-de...

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Detalles Bibliográficos
Autores principales:	Shinohara, Ken-ichi, Yoda, Natsumi, Takane, Kiyoko, Watanabe, Takayoshi, Fukuyo, Masaki, Fujiwara, Kyoko, Kita, Kazuko, Nagase, Hiroki, Nemoto, Tetsuhiro, Kaneda, Atsushi
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Chemical Society 2016
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6044701/ https://www.ncbi.nlm.nih.gov/pubmed/30023504 http://dx.doi.org/10.1021/acsomega.6b00229

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