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Defect-Mediated Reactive Oxygen Species Generation in Mg-Substituted ZnO Nanoparticles: Efficient Nanomaterials for Bacterial Inhibition and Cancer Therapy

[Image: see text] Mg-substituted ZnO nanoparticles (MgZnO NPs) were synthesized by a soft chemical approach and were well-characterized by X-ray diffraction, transmission electron microscopy, UV–visible spectroscopy, and photoluminescence spectroscopy. The absorption and photoluminescence spectra sh...

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Autores principales: Gupta, Jagriti, Bahadur, D.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2018
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6044716/
https://www.ncbi.nlm.nih.gov/pubmed/30023854
http://dx.doi.org/10.1021/acsomega.7b01953
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author Gupta, Jagriti
Bahadur, D.
author_facet Gupta, Jagriti
Bahadur, D.
author_sort Gupta, Jagriti
collection PubMed
description [Image: see text] Mg-substituted ZnO nanoparticles (MgZnO NPs) were synthesized by a soft chemical approach and were well-characterized by X-ray diffraction, transmission electron microscopy, UV–visible spectroscopy, and photoluminescence spectroscopy. The absorption and photoluminescence spectra show that substitution of Mg ions results in the widening of the band gap and a significant enhancement in the concentration of defects in ZnO NPs. A systemic study of generation of reactive oxygen species (ROS) under dark, daylight, and visible light conditions suggests that the aqueous suspension of MgZnO NPs generates a higher level of ROS because of the surface defects (oxygen vacancies). This capability of MgZnO NPs makes them a more promising candidate for the inhibition of bacterial growth and for killing of cancer cells as compared to pure ZnO NPs, possibly because of the enhanced interaction and accumulation of MgZnO NPs in the cytoplasm or cell membrane in the presence of both Zn(2+) and Mg(2+) ions. Further, MgZnO NPs exhibit excellent selective killing of nasopharyngeal carcinoma cells (KB) and cervical cancer cells (HeLa) with minimal toxicity to normal fibroblast cells (L929). The results suggest that the generation of ROS and Zn(2+) ions are possibly responsible for the higher activity toward the depolarization of cell membrane potential, the lipid peroxidation in bacterial cells, depolarization of the mitochondrial membrane, and cell cycle arrest in the S phase in cancer cells.
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spelling pubmed-60447162018-07-16 Defect-Mediated Reactive Oxygen Species Generation in Mg-Substituted ZnO Nanoparticles: Efficient Nanomaterials for Bacterial Inhibition and Cancer Therapy Gupta, Jagriti Bahadur, D. ACS Omega [Image: see text] Mg-substituted ZnO nanoparticles (MgZnO NPs) were synthesized by a soft chemical approach and were well-characterized by X-ray diffraction, transmission electron microscopy, UV–visible spectroscopy, and photoluminescence spectroscopy. The absorption and photoluminescence spectra show that substitution of Mg ions results in the widening of the band gap and a significant enhancement in the concentration of defects in ZnO NPs. A systemic study of generation of reactive oxygen species (ROS) under dark, daylight, and visible light conditions suggests that the aqueous suspension of MgZnO NPs generates a higher level of ROS because of the surface defects (oxygen vacancies). This capability of MgZnO NPs makes them a more promising candidate for the inhibition of bacterial growth and for killing of cancer cells as compared to pure ZnO NPs, possibly because of the enhanced interaction and accumulation of MgZnO NPs in the cytoplasm or cell membrane in the presence of both Zn(2+) and Mg(2+) ions. Further, MgZnO NPs exhibit excellent selective killing of nasopharyngeal carcinoma cells (KB) and cervical cancer cells (HeLa) with minimal toxicity to normal fibroblast cells (L929). The results suggest that the generation of ROS and Zn(2+) ions are possibly responsible for the higher activity toward the depolarization of cell membrane potential, the lipid peroxidation in bacterial cells, depolarization of the mitochondrial membrane, and cell cycle arrest in the S phase in cancer cells. American Chemical Society 2018-03-12 /pmc/articles/PMC6044716/ /pubmed/30023854 http://dx.doi.org/10.1021/acsomega.7b01953 Text en Copyright © 2018 American Chemical Society This is an open access article published under an ACS AuthorChoice License (http://pubs.acs.org/page/policy/authorchoice_termsofuse.html) , which permits copying and redistribution of the article or any adaptations for non-commercial purposes.
spellingShingle Gupta, Jagriti
Bahadur, D.
Defect-Mediated Reactive Oxygen Species Generation in Mg-Substituted ZnO Nanoparticles: Efficient Nanomaterials for Bacterial Inhibition and Cancer Therapy
title Defect-Mediated Reactive Oxygen Species Generation in Mg-Substituted ZnO Nanoparticles: Efficient Nanomaterials for Bacterial Inhibition and Cancer Therapy
title_full Defect-Mediated Reactive Oxygen Species Generation in Mg-Substituted ZnO Nanoparticles: Efficient Nanomaterials for Bacterial Inhibition and Cancer Therapy
title_fullStr Defect-Mediated Reactive Oxygen Species Generation in Mg-Substituted ZnO Nanoparticles: Efficient Nanomaterials for Bacterial Inhibition and Cancer Therapy
title_full_unstemmed Defect-Mediated Reactive Oxygen Species Generation in Mg-Substituted ZnO Nanoparticles: Efficient Nanomaterials for Bacterial Inhibition and Cancer Therapy
title_short Defect-Mediated Reactive Oxygen Species Generation in Mg-Substituted ZnO Nanoparticles: Efficient Nanomaterials for Bacterial Inhibition and Cancer Therapy
title_sort defect-mediated reactive oxygen species generation in mg-substituted zno nanoparticles: efficient nanomaterials for bacterial inhibition and cancer therapy
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6044716/
https://www.ncbi.nlm.nih.gov/pubmed/30023854
http://dx.doi.org/10.1021/acsomega.7b01953
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