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Discovery of Retinoic Acid-Related Orphan Receptor γt Inverse Agonists via Docking and Negative Image-Based Screening

[Image: see text] Retinoic acid-related orphan receptor γt (RORγt) has a vital role in the differentiation of T-helper 17 (TH17) cells. Potent and specific RORγt inverse agonists are sought for treating TH17-related diseases such as psoriasis, rheumatoid arthritis, and type 1 diabetes. Here, the aim...

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Detalles Bibliográficos
Autores principales:	Rauhamäki, Sanna, Postila, Pekka A., Lätti, Sakari, Niinivehmas, Sanna, Multamäki, Elina, Liedl, Klaus R., Pentikäinen, Olli T.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Chemical Society 2018
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6044741/ https://www.ncbi.nlm.nih.gov/pubmed/30023945 http://dx.doi.org/10.1021/acsomega.8b00603

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