Cargando…

Diclofenac Identified as a Kynurenine 3-Monooxygenase Binder and Inhibitor by Molecular Similarity Techniques

[Image: see text] In this study, we apply a battery of molecular similarity techniques to known inhibitors of kynurenine 3-monooxygenase (KMO), querying each against a repository of approved, experimental, nutraceutical, and illicit drugs. Four compounds are assayed against KMO. Subsequently, diclof...

Descripción completa

Detalles Bibliográficos
Autores principales:	Shave, Steven, McGuire, Kris, Pham, Nhan T., Mole, Damian J., Webster, Scott P., Auer, Manfred
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Chemical Society 2018
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6044753/ https://www.ncbi.nlm.nih.gov/pubmed/30023839 http://dx.doi.org/10.1021/acsomega.7b02091

Ejemplares similares

Kynurenine 3-monooxygenase is a critical regulator of renal ischemia–reperfusion injury
por: Zheng, Xiaozhong, et al.
Publicado: (2019)

Bacterial expression of human kynurenine 3-monooxygenase: Solubility, activity, purification()
por: Wilson, K., et al.
Publicado: (2014)

Overexpression of human kynurenine-3-monooxygenase protects against 3-hydroxykynurenine-mediated apoptosis through bidirectional nonlinear feedback
por: Wilson, K, et al.
Publicado: (2016)

The Kynurenine Pathway and Kynurenine 3-Monooxygenase Inhibitors
por: Hughes, Tamera D., et al.
Publicado: (2022)

Structural and mechanistic basis of differentiated inhibitors of the acute pancreatitis target kynurenine-3-monooxygenase
por: Hutchinson, Jonathan P., et al.
Publicado: (2017)

Modulation of Enzyme Activity in the Kynurenine Pathway by Kynurenine Monooxygenase Inhibition
por: Phillips, Robert S., et al.
Publicado: (2019)

Kynurenine–3–monooxygenase inhibition prevents multiple organ failure in rodent models of acute pancreatitis
por: Mole, Damian J, et al.
Publicado: (2016)

CLAffinity: A Software Tool for Identification of Optimum Ligand Affinity for Competition-Based Primary Screens
por: Shave, Steven, et al.
Publicado: (2022)

Structural basis of kynurenine 3-monooxygenase inhibition
por: Amaral, Marta, et al.
Publicado: (2013)

Kynurenine 3-Monooxygenase: An Influential Mediator of Neuropathology
por: Parrott, Jennifer M., et al.
Publicado: (2015)

Kynurenine Monooxygenase Expression and Activity in Human Astrocytomas
por: Vázquez Cervantes, Gustavo Ignacio, et al.
Publicado: (2021)

Significance of Kynurenine 3-Monooxygenase Expression in Colorectal Cancer
por: Liu, Chun-Yu, et al.
Publicado: (2021)

Quantitative Microdialysis: Experimental Protocol and Software for Small Molecule Protein Affinity Determination and for Exclusion of Compounds with Poor Physicochemical Properties
por: Shave, Steven, et al.
Publicado: (2020)

PyBindingCurve, Simulation, and Curve Fitting to Complex Binding Systems at Equilibrium
por: Shave, Steven, et al.
Publicado: (2021)

A novel role for kynurenine 3-monooxygenase in mitochondrial dynamics
por: Maddison, Daniel C., et al.
Publicado: (2020)

Cellular Localization of Kynurenine 3-Monooxygenase in the Brain: Challenging the Dogma
por: Sathyasaikumar, Korrapati V., et al.
Publicado: (2022)

Kynurenine 3-Monooxygenase Interacts with Huntingtin at the Outer Mitochondrial Membrane
por: Swaih, Aisha M., et al.
Publicado: (2022)

Kynurenine‐3‐monooxygenase: A new direction for the treatment in different diseases
por: Lu, Yifei, et al.
Publicado: (2020)

Blockade of KAT II Facilitates LTP in Kynurenine 3-Monooxygenase Depleted Mice
por: Imbeault, Sophie, et al.
Publicado: (2021)

Full-length in meso structure and mechanism of rat kynurenine 3-monooxygenase inhibition
por: Mimasu, Shinya, et al.
Publicado: (2021)

Protective Role of Kynurenine 3-Monooxygenase in Allograft Rejection and Tubular Injury in Kidney Transplantation
por: Lassiter, Randi, et al.
Publicado: (2021)

Prognostic significance of kynurenine 3-monooxygenase and effects on proliferation, migration, and invasion of human hepatocellular carcinoma
por: Jin, Haojie, et al.
Publicado: (2015)

Viability of diffuse large B-cell lymphoma cells is regulated by kynurenine 3-monooxygenase activity
por: Morita, Nanaka, et al.
Publicado: (2021)

Surface Expression of Kynurenine 3-Monooxygenase Promotes Proliferation and Metastasis in Triple-Negative Breast Cancers
por: Lai, Min-Hua, et al.
Publicado: (2021)

Protocatechuic acid prevents isoproterenol‐induced heart failure in mice by downregulating kynurenine‐3‐monooxygenase
por: Bai, Liyan, et al.
Publicado: (2023)

Pharmacological Inhibition of Indoleamine 2,3-Dioxygenase-2 and Kynurenine 3-Monooxygenase, Enzymes of the Kynurenine Pathway, Significantly Diminishes Neuropathic Pain in a Rat Model
por: Rojewska, Ewelina, et al.
Publicado: (2018)

The Kynurenine 3-Monooxygenase Encoding Gene, BcKMO, Is Involved in the Growth, Development, and Pathogenicity of Botrytis cinerea
por: Zhang, Kang, et al.
Publicado: (2018)

Peripheral kynurenine-3-monooxygenase deficiency as a potential risk factor for metabolic syndrome in schizophrenia patients
por: Oxenkrug, Gregory, et al.
Publicado: (2017)

Pharmacophore-Based Virtual Screening of Novel Competitive Inhibitors of the Neurodegenerative Disease Target Kynurenine-3-Monooxygenase
por: Gotina, Lizaveta, et al.
Publicado: (2021)

A brain-permeable inhibitor of the neurodegenerative disease target kynurenine 3-monooxygenase prevents accumulation of neurotoxic metabolites
por: Zhang, Shaowei, et al.
Publicado: (2019)

Overexpression of Kynurenine 3-Monooxygenase Correlates with Cancer Malignancy and Predicts Poor Prognosis in Canine Mammary Gland Tumors
por: Chiu, Yi-Han, et al.
Publicado: (2019)

Inflammation control and improvement of cognitive function in COVID-19 infections: is there a role for kynurenine 3-monooxygenase inhibition?
por: Collier, Mary EW, et al.
Publicado: (2021)

Integrated Molecular Characterization to Reveal the Association between Kynurenine 3-Monooxygenase Expression and Tumorigenesis in Human Breast Cancers
por: Tsang, Yuk-Wah, et al.
Publicado: (2021)

Kynurenine 3-Monooxygenase Gene Associated With Nicotine Initiation and Addiction: Analysis of Novel Regulatory Features at 5′ and 3′-Regions
por: Aziz, Hassan A., et al.
Publicado: (2018)

Kynurenine 3-monooxygenase upregulates pluripotent genes through β-catenin and promotes triple-negative breast cancer progression
por: Huang, Tzu-Ting, et al.
Publicado: (2020)

Immunometabolic Network Interactions of the Kynurenine Pathway in Cutaneous Malignant Melanoma
por: Rad Pour, Soudabeh, et al.
Publicado: (2020)

Ablation of kynurenine 3-monooxygenase rescues plasma inflammatory cytokine levels in the R6/2 mouse model of Huntington’s disease
por: Bondulich, Marie Katrin, et al.
Publicado: (2021)

Real-time tracking of complex ubiquitination cascades using a fluorescent confocal on-bead assay
por: Koszela, Joanna, et al.
Publicado: (2018)

Gram-Scale Preparation of Cannflavin A from Hemp (Cannabis sativa L.) and Its Inhibitory Effect on Tryptophan Catabolism Enzyme Kynurenine-3-Monooxygenase
por: Puopolo, Tess, et al.
Publicado: (2022)

PuLSE: Quality control and quantification of peptide sequences explored by phage display libraries
por: Shave, Steven, et al.
Publicado: (2018)

Cannot write session to /tmp/vufind_sessions/sess_h4raccpdc0kisls5447itthhd3