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Gram-Scale Synthesis of a β-Secretase 1 (BACE 1) Inhibitor
[Image: see text] Development of a scalable synthesis of an oxazine class of β-secretase inhibitor is described. Trifluoromethylated acyloin synthesis by the reaction of a mandelic acid with trifluoroacetic anhydride in the presence of pyridine (Dakin–West reaction) was used as an efficient strategy...
| Autores principales: | , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
American Chemical Society
2017
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6044763/ https://www.ncbi.nlm.nih.gov/pubmed/30023606 http://dx.doi.org/10.1021/acsomega.6b00362 |