Hydroxyl Ketone-Based Histone Deacetylase Inhibitors To Gain Insight into Class I HDAC Selectivity versus That of HDAC6

[Image: see text] Little is known about the biological and structural features that govern the isoform selectivity for class I histone deacetylases (HDACs) over HDAC6. In addition to that for known inhibitors, like benzamides, psammaplin A, and cyclodepsipeptide-derived thiols, selectivity was also...

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Detalles Bibliográficos
Autores principales: Traoré, Mohamed D. M., Zwick, Vincent, Simões-Pires, Claudia A., Nurisso, Alessandra, Issa, Mark, Cuendet, Muriel, Maynadier, Marjorie, Wein, Sharon, Vial, Henri, Jamet, Helene, Wong, Yung-Sing
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2017
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6044785/
https://www.ncbi.nlm.nih.gov/pubmed/30023639
http://dx.doi.org/10.1021/acsomega.6b00481

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