Selagintamarlin A: A Selaginellin Analogue Possessing a 1H-2-Benzopyran Core from Selaginella tamariscina

[Image: see text] Selagintamarlin A (1), a novel selaginellin analogue featuring the unique motif of 1H-2-benzopyran, a new selaginpulvilin E (2), together with eight known analogues were isolated from Selaginella tamariscina. Their structures were elucidated by extensive spectroscopic analyses. A p...

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Detalles Bibliográficos
Autores principales: Yao, Wei-Na, Huang, Ri-Zhen, Hua, Jing, Zhang, Bin, Wang, Chun-Gu, Liang, Dong, Wang, Heng-Shan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2017
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6044830/
https://www.ncbi.nlm.nih.gov/pubmed/30023657
http://dx.doi.org/10.1021/acsomega.7b00209
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author Yao, Wei-Na
Huang, Ri-Zhen
Hua, Jing
Zhang, Bin
Wang, Chun-Gu
Liang, Dong
Wang, Heng-Shan
author_facet Yao, Wei-Na
Huang, Ri-Zhen
Hua, Jing
Zhang, Bin
Wang, Chun-Gu
Liang, Dong
Wang, Heng-Shan
author_sort Yao, Wei-Na
collection PubMed
description [Image: see text] Selagintamarlin A (1), a novel selaginellin analogue featuring the unique motif of 1H-2-benzopyran, a new selaginpulvilin E (2), together with eight known analogues were isolated from Selaginella tamariscina. Their structures were elucidated by extensive spectroscopic analyses. A plausible biosynthetic pathway of 1 was also postulated. Compound 1 showed remarkable inhibitory activity against phosphodiesterase-4 (PDE4D2), with an IC(50) value of 40 nM, which is 20-fold higher than that of the positive control (rolipram). Furthermore, compound 1 significantly inhibited tubulin polymerization.
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spelling pubmed-60448302018-07-16 Selagintamarlin A: A Selaginellin Analogue Possessing a 1H-2-Benzopyran Core from Selaginella tamariscina Yao, Wei-Na Huang, Ri-Zhen Hua, Jing Zhang, Bin Wang, Chun-Gu Liang, Dong Wang, Heng-Shan ACS Omega [Image: see text] Selagintamarlin A (1), a novel selaginellin analogue featuring the unique motif of 1H-2-benzopyran, a new selaginpulvilin E (2), together with eight known analogues were isolated from Selaginella tamariscina. Their structures were elucidated by extensive spectroscopic analyses. A plausible biosynthetic pathway of 1 was also postulated. Compound 1 showed remarkable inhibitory activity against phosphodiesterase-4 (PDE4D2), with an IC(50) value of 40 nM, which is 20-fold higher than that of the positive control (rolipram). Furthermore, compound 1 significantly inhibited tubulin polymerization. American Chemical Society 2017-05-17 /pmc/articles/PMC6044830/ /pubmed/30023657 http://dx.doi.org/10.1021/acsomega.7b00209 Text en Copyright © 2017 American Chemical Society This is an open access article published under an ACS AuthorChoice License (http://pubs.acs.org/page/policy/authorchoice_termsofuse.html) , which permits copying and redistribution of the article or any adaptations for non-commercial purposes.
spellingShingle Yao, Wei-Na
Huang, Ri-Zhen
Hua, Jing
Zhang, Bin
Wang, Chun-Gu
Liang, Dong
Wang, Heng-Shan
Selagintamarlin A: A Selaginellin Analogue Possessing a 1H-2-Benzopyran Core from Selaginella tamariscina
title Selagintamarlin A: A Selaginellin Analogue Possessing a 1H-2-Benzopyran Core from Selaginella tamariscina
title_full Selagintamarlin A: A Selaginellin Analogue Possessing a 1H-2-Benzopyran Core from Selaginella tamariscina
title_fullStr Selagintamarlin A: A Selaginellin Analogue Possessing a 1H-2-Benzopyran Core from Selaginella tamariscina
title_full_unstemmed Selagintamarlin A: A Selaginellin Analogue Possessing a 1H-2-Benzopyran Core from Selaginella tamariscina
title_short Selagintamarlin A: A Selaginellin Analogue Possessing a 1H-2-Benzopyran Core from Selaginella tamariscina
title_sort selagintamarlin a: a selaginellin analogue possessing a 1h-2-benzopyran core from selaginella tamariscina
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6044830/
https://www.ncbi.nlm.nih.gov/pubmed/30023657
http://dx.doi.org/10.1021/acsomega.7b00209
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