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Energetics of Preferential Binding of Retinoic Acid-Inducible Gene-I to Double-Stranded Viral RNAs with 5′ Tri-/Diphosphate over 5′ Monophosphate

[Image: see text] Retinoic acid-inducible gene-I (RIG-I) is a cytosolic sensor protein that recognizes viral RNAs and triggers an innate immune response in cells. Panhandle-like base-paired blunt-ended 5′ ppp/pp-dsRNA is a characteristic feature of viral RNAs. Structural studies of RIG-I C-terminal...

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Detalles Bibliográficos
Autores principales:	Kumar, Amit, Satpati, Priyadarshi
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Chemical Society 2018
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6044841/ https://www.ncbi.nlm.nih.gov/pubmed/30023880 http://dx.doi.org/10.1021/acsomega.7b02019

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