Efforts To Access the Potent Antitrypanosomal Marine Natural Product Janadolide: Synthesis of Des-tert-butyl Janadolide and Its Biological Evaluation

[Image: see text] To identify novel antitrypanosomal agents based on Janadolide, a potent macrocyclic polyketide–peptide hybrid, a macrolactonization strategy was explored. We prepared des-tert-butyl Janadolide and evaluated its antitrypanosomal activity. Our findings suggest that the tert-butyl gro...

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Autores principales: Athawale, Paresh R., Jachak, Gorakhnath R., Shukla, Anurag, Shanmugam, Dhanasekaran, Reddy, D. Srinivasa
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2018
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6044843/
https://www.ncbi.nlm.nih.gov/pubmed/30023831
http://dx.doi.org/10.1021/acsomega.7b01920
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author Athawale, Paresh R.
Jachak, Gorakhnath R.
Shukla, Anurag
Shanmugam, Dhanasekaran
Reddy, D. Srinivasa
author_facet Athawale, Paresh R.
Jachak, Gorakhnath R.
Shukla, Anurag
Shanmugam, Dhanasekaran
Reddy, D. Srinivasa
author_sort Athawale, Paresh R.
collection PubMed
description [Image: see text] To identify novel antitrypanosomal agents based on Janadolide, a potent macrocyclic polyketide–peptide hybrid, a macrolactonization strategy was explored. We prepared des-tert-butyl Janadolide and evaluated its antitrypanosomal activity. Our findings suggest that the tert-butyl group is necessary for the desired bioactivity.
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spelling pubmed-60448432018-07-16 Efforts To Access the Potent Antitrypanosomal Marine Natural Product Janadolide: Synthesis of Des-tert-butyl Janadolide and Its Biological Evaluation Athawale, Paresh R. Jachak, Gorakhnath R. Shukla, Anurag Shanmugam, Dhanasekaran Reddy, D. Srinivasa ACS Omega [Image: see text] To identify novel antitrypanosomal agents based on Janadolide, a potent macrocyclic polyketide–peptide hybrid, a macrolactonization strategy was explored. We prepared des-tert-butyl Janadolide and evaluated its antitrypanosomal activity. Our findings suggest that the tert-butyl group is necessary for the desired bioactivity. American Chemical Society 2018-02-27 /pmc/articles/PMC6044843/ /pubmed/30023831 http://dx.doi.org/10.1021/acsomega.7b01920 Text en Copyright © 2018 American Chemical Society This is an open access article published under an ACS AuthorChoice License (http://pubs.acs.org/page/policy/authorchoice_termsofuse.html) , which permits copying and redistribution of the article or any adaptations for non-commercial purposes.
spellingShingle Athawale, Paresh R.
Jachak, Gorakhnath R.
Shukla, Anurag
Shanmugam, Dhanasekaran
Reddy, D. Srinivasa
Efforts To Access the Potent Antitrypanosomal Marine Natural Product Janadolide: Synthesis of Des-tert-butyl Janadolide and Its Biological Evaluation
title Efforts To Access the Potent Antitrypanosomal Marine Natural Product Janadolide: Synthesis of Des-tert-butyl Janadolide and Its Biological Evaluation
title_full Efforts To Access the Potent Antitrypanosomal Marine Natural Product Janadolide: Synthesis of Des-tert-butyl Janadolide and Its Biological Evaluation
title_fullStr Efforts To Access the Potent Antitrypanosomal Marine Natural Product Janadolide: Synthesis of Des-tert-butyl Janadolide and Its Biological Evaluation
title_full_unstemmed Efforts To Access the Potent Antitrypanosomal Marine Natural Product Janadolide: Synthesis of Des-tert-butyl Janadolide and Its Biological Evaluation
title_short Efforts To Access the Potent Antitrypanosomal Marine Natural Product Janadolide: Synthesis of Des-tert-butyl Janadolide and Its Biological Evaluation
title_sort efforts to access the potent antitrypanosomal marine natural product janadolide: synthesis of des-tert-butyl janadolide and its biological evaluation
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6044843/
https://www.ncbi.nlm.nih.gov/pubmed/30023831
http://dx.doi.org/10.1021/acsomega.7b01920
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