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Enantioselective Synthesis of a Novel Thiazoline Core as a Potent Peroxisome Proliferator-Activated Receptor δ Agonist
[Image: see text] The convergent and enantioselective synthesis of a highly potent human peroxisome proliferator-activated receptor delta agonist is presented. More specifically, the thiazoline structure, which constitutes the biosynthetically distinctive core structure of pulicatin (a secondary met...
Autores principales: | , , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
American Chemical Society
2018
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6044852/ https://www.ncbi.nlm.nih.gov/pubmed/30023820 http://dx.doi.org/10.1021/acsomega.7b01689 |
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author | Lee, Su-Jeong Samala, Mallesham Woo, Seo Yeon Hahn, Dongyup Kim, Dayoung Kadayat, Tara Man Jung, Kyungjin Kim, Jina Kim, Dong-Su Kwon, Sugyeong Kim, Shinae Kim, Kyung-Hee Nam, Sang-Jip Cho, Sung Jin Chin, Jungwook |
author_facet | Lee, Su-Jeong Samala, Mallesham Woo, Seo Yeon Hahn, Dongyup Kim, Dayoung Kadayat, Tara Man Jung, Kyungjin Kim, Jina Kim, Dong-Su Kwon, Sugyeong Kim, Shinae Kim, Kyung-Hee Nam, Sang-Jip Cho, Sung Jin Chin, Jungwook |
author_sort | Lee, Su-Jeong |
collection | PubMed |
description | [Image: see text] The convergent and enantioselective synthesis of a highly potent human peroxisome proliferator-activated receptor delta agonist is presented. More specifically, the thiazoline structure, which constitutes the biosynthetically distinctive core structure of pulicatin (a secondary metabolite of symbiotic bacteria), was synthesized from a commercially available and inexpensive chiral pool of l-threonine. |
format | Online Article Text |
id | pubmed-6044852 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2018 |
publisher | American Chemical Society |
record_format | MEDLINE/PubMed |
spelling | pubmed-60448522018-07-16 Enantioselective Synthesis of a Novel Thiazoline Core as a Potent Peroxisome Proliferator-Activated Receptor δ Agonist Lee, Su-Jeong Samala, Mallesham Woo, Seo Yeon Hahn, Dongyup Kim, Dayoung Kadayat, Tara Man Jung, Kyungjin Kim, Jina Kim, Dong-Su Kwon, Sugyeong Kim, Shinae Kim, Kyung-Hee Nam, Sang-Jip Cho, Sung Jin Chin, Jungwook ACS Omega [Image: see text] The convergent and enantioselective synthesis of a highly potent human peroxisome proliferator-activated receptor delta agonist is presented. More specifically, the thiazoline structure, which constitutes the biosynthetically distinctive core structure of pulicatin (a secondary metabolite of symbiotic bacteria), was synthesized from a commercially available and inexpensive chiral pool of l-threonine. American Chemical Society 2018-02-15 /pmc/articles/PMC6044852/ /pubmed/30023820 http://dx.doi.org/10.1021/acsomega.7b01689 Text en Copyright © 2018 American Chemical Society This is an open access article published under an ACS AuthorChoice License (http://pubs.acs.org/page/policy/authorchoice_termsofuse.html) , which permits copying and redistribution of the article or any adaptations for non-commercial purposes. |
spellingShingle | Lee, Su-Jeong Samala, Mallesham Woo, Seo Yeon Hahn, Dongyup Kim, Dayoung Kadayat, Tara Man Jung, Kyungjin Kim, Jina Kim, Dong-Su Kwon, Sugyeong Kim, Shinae Kim, Kyung-Hee Nam, Sang-Jip Cho, Sung Jin Chin, Jungwook Enantioselective Synthesis of a Novel Thiazoline Core as a Potent Peroxisome Proliferator-Activated Receptor δ Agonist |
title | Enantioselective Synthesis of a Novel Thiazoline Core
as a Potent Peroxisome Proliferator-Activated Receptor δ Agonist |
title_full | Enantioselective Synthesis of a Novel Thiazoline Core
as a Potent Peroxisome Proliferator-Activated Receptor δ Agonist |
title_fullStr | Enantioselective Synthesis of a Novel Thiazoline Core
as a Potent Peroxisome Proliferator-Activated Receptor δ Agonist |
title_full_unstemmed | Enantioselective Synthesis of a Novel Thiazoline Core
as a Potent Peroxisome Proliferator-Activated Receptor δ Agonist |
title_short | Enantioselective Synthesis of a Novel Thiazoline Core
as a Potent Peroxisome Proliferator-Activated Receptor δ Agonist |
title_sort | enantioselective synthesis of a novel thiazoline core
as a potent peroxisome proliferator-activated receptor δ agonist |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6044852/ https://www.ncbi.nlm.nih.gov/pubmed/30023820 http://dx.doi.org/10.1021/acsomega.7b01689 |
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