Sequential Synthesis, Olfactory Properties, and Biological Activity of Quinoxaline Derivatives

[Image: see text] A simple, practical, and rapid access to quinoxalin-2-ones 1, 1,2,3,4-tetrahydroquinoxalines 2, quinoxalines 3, and quinoxalin-2(1H)-ones 4 has been achieved, based on the copper-catalyzed quinoxalinone formation of 2-haloanilines and amino acids followed by their reduction and oxi...

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Detalles Bibliográficos
Autores principales: Imanishi, Mia, Sonoda, Motohiro, Miyazato, Hironari, Sugimoto, Keiichiro, Akagawa, Mitsugu, Tanimori, Shinji
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2017
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6044855/
https://www.ncbi.nlm.nih.gov/pubmed/30023648
http://dx.doi.org/10.1021/acsomega.7b00124
Descripción
Sumario:[Image: see text] A simple, practical, and rapid access to quinoxalin-2-ones 1, 1,2,3,4-tetrahydroquinoxalines 2, quinoxalines 3, and quinoxalin-2(1H)-ones 4 has been achieved, based on the copper-catalyzed quinoxalinone formation of 2-haloanilines and amino acids followed by their reduction and oxidation. The olfactory properties and lipid accumulation inhibitory activity in cultured hepatocytes of the quinoxaline derivatives were also evaluated.

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