Sequential Synthesis, Olfactory Properties, and Biological Activity of Quinoxaline Derivatives

[Image: see text] A simple, practical, and rapid access to quinoxalin-2-ones 1, 1,2,3,4-tetrahydroquinoxalines 2, quinoxalines 3, and quinoxalin-2(1H)-ones 4 has been achieved, based on the copper-catalyzed quinoxalinone formation of 2-haloanilines and amino acids followed by their reduction and oxi...

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Autores principales: Imanishi, Mia, Sonoda, Motohiro, Miyazato, Hironari, Sugimoto, Keiichiro, Akagawa, Mitsugu, Tanimori, Shinji
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2017
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6044855/
https://www.ncbi.nlm.nih.gov/pubmed/30023648
http://dx.doi.org/10.1021/acsomega.7b00124
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author Imanishi, Mia
Sonoda, Motohiro
Miyazato, Hironari
Sugimoto, Keiichiro
Akagawa, Mitsugu
Tanimori, Shinji
author_facet Imanishi, Mia
Sonoda, Motohiro
Miyazato, Hironari
Sugimoto, Keiichiro
Akagawa, Mitsugu
Tanimori, Shinji
author_sort Imanishi, Mia
collection PubMed
description [Image: see text] A simple, practical, and rapid access to quinoxalin-2-ones 1, 1,2,3,4-tetrahydroquinoxalines 2, quinoxalines 3, and quinoxalin-2(1H)-ones 4 has been achieved, based on the copper-catalyzed quinoxalinone formation of 2-haloanilines and amino acids followed by their reduction and oxidation. The olfactory properties and lipid accumulation inhibitory activity in cultured hepatocytes of the quinoxaline derivatives were also evaluated.
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spelling pubmed-60448552018-07-16 Sequential Synthesis, Olfactory Properties, and Biological Activity of Quinoxaline Derivatives Imanishi, Mia Sonoda, Motohiro Miyazato, Hironari Sugimoto, Keiichiro Akagawa, Mitsugu Tanimori, Shinji ACS Omega [Image: see text] A simple, practical, and rapid access to quinoxalin-2-ones 1, 1,2,3,4-tetrahydroquinoxalines 2, quinoxalines 3, and quinoxalin-2(1H)-ones 4 has been achieved, based on the copper-catalyzed quinoxalinone formation of 2-haloanilines and amino acids followed by their reduction and oxidation. The olfactory properties and lipid accumulation inhibitory activity in cultured hepatocytes of the quinoxaline derivatives were also evaluated. American Chemical Society 2017-05-08 /pmc/articles/PMC6044855/ /pubmed/30023648 http://dx.doi.org/10.1021/acsomega.7b00124 Text en Copyright © 2017 American Chemical Society This is an open access article published under an ACS AuthorChoice License (http://pubs.acs.org/page/policy/authorchoice_termsofuse.html) , which permits copying and redistribution of the article or any adaptations for non-commercial purposes.
spellingShingle Imanishi, Mia
Sonoda, Motohiro
Miyazato, Hironari
Sugimoto, Keiichiro
Akagawa, Mitsugu
Tanimori, Shinji
Sequential Synthesis, Olfactory Properties, and Biological Activity of Quinoxaline Derivatives
title Sequential Synthesis, Olfactory Properties, and Biological Activity of Quinoxaline Derivatives
title_full Sequential Synthesis, Olfactory Properties, and Biological Activity of Quinoxaline Derivatives
title_fullStr Sequential Synthesis, Olfactory Properties, and Biological Activity of Quinoxaline Derivatives
title_full_unstemmed Sequential Synthesis, Olfactory Properties, and Biological Activity of Quinoxaline Derivatives
title_short Sequential Synthesis, Olfactory Properties, and Biological Activity of Quinoxaline Derivatives
title_sort sequential synthesis, olfactory properties, and biological activity of quinoxaline derivatives
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6044855/
https://www.ncbi.nlm.nih.gov/pubmed/30023648
http://dx.doi.org/10.1021/acsomega.7b00124
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