Cargando…
Macrophage migration inhibitory factor is critical for dengue NS1-induced endothelial glycocalyx degradation and hyperpermeability
Vascular leakage is one of the salient characteristics of severe dengue. Nonstructural protein 1 (NS1) of dengue virus (DENV) can stimulate endothelial cells to secrete endothelial hyperpermeability factor, macrophage migration inhibitory factor (MIF), and the glycocalyx degradation factor heparanas...
Autores principales: | Chen, Hong-Ru, Chao, Chiao-Hsuan, Liu, Ching-Chuan, Ho, Tzong-Shiann, Tsai, Huey-Pin, Perng, Guey-Chuen, Lin, Yee-Shin, Wang, Jen-Ren, Yeh, Trai-Ming |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Public Library of Science
2018
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6044858/ https://www.ncbi.nlm.nih.gov/pubmed/29702687 http://dx.doi.org/10.1371/journal.ppat.1007033 |
Ejemplares similares
-
Dengue Virus NS1 Disrupts the Endothelial Glycocalyx, Leading to Hyperpermeability
por: Puerta-Guardo, Henry, et al.
Publicado: (2016) -
Dengue Virus Nonstructural Protein 1 Induces Vascular Leakage through Macrophage Migration Inhibitory Factor and Autophagy
por: Chen, Hong-Ru, et al.
Publicado: (2016) -
Antibodies Against Modified NS1 Wing Domain Peptide Protect Against Dengue Virus Infection
por: Lai, Yen-Chung, et al.
Publicado: (2017) -
Dengue virus nonstructural protein 1 activates platelets via Toll-like receptor 4, leading to thrombocytopenia and hemorrhage
por: Chao, Chiao-Hsuan, et al.
Publicado: (2019) -
Dynamic changes of soluble ST2 levels predicted fatality and were involved in coagulopathy in dengue fever in the elderly
por: Hsieh, Chih-Cheng, et al.
Publicado: (2019)