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Tautomeric-Dependent Lactam Cycloaddition with Nitrile Oxide: Facile Synthesis of 1,2,4-Oxadiazole[4,5-a]indolone Derivatives

[Image: see text] A concise, metal-free, and gram-scale strategy to convert indoline-2,3-diones to 1,2,4-oxadiazole[4,5-a]indolones through an improved [3 + 2] cycloaddition of α-ketone-lactam with nitrile oxides has been developed. The lactim form of the resonance structure of isatin in protic solv...

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Detalles Bibliográficos
Autores principales:	Jiang, Kun-Ming, Luesakul, Urarika, Zhao, Shu-Yue, An, Kun, Muangsin, Nongnuj, Neamati, Nouri, Jin, Yi, Lin, Jun
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Chemical Society 2017
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6044867/ https://www.ncbi.nlm.nih.gov/pubmed/30023685 http://dx.doi.org/10.1021/acsomega.7b00490

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