Heterodimerization of Dibenzodiazepinone-Type Muscarinic Acetylcholine Receptor Ligands Leads to Increased M(2)R Affinity and Selectivity

[Image: see text] In search for selective ligands for the muscarinic acetylcholine receptor (MR) subtype M(2), the dimeric ligand approach, that is combining two pharmacophores in one and the same molecule, was pursued. Different types (agonists, antagonists, orthosteric, and allosteric) of monomeri...

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Detalles Bibliográficos
Autores principales: She, Xueke, Pegoli, Andrea, Mayr, Judith, Hübner, Harald, Bernhardt, Günther, Gmeiner, Peter, Keller, Max
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2017
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6044897/
https://www.ncbi.nlm.nih.gov/pubmed/30023530
http://dx.doi.org/10.1021/acsomega.7b01085

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